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| Caption | The Osr1tm2.1Jian/Osr1tm2.1Jian embryos die prenatally. A, B: A pair of Osr1tm2.1Jian/Osr1+ (A) and Osr1tm2.1Jian/Osr1tm2.1Jian (B) embryos harvested at E12.0. Note the homozygous mutant embryo had dilated epicardium (arrow in B) and showed hemorrhaging in the trunk region. C-E: Heterozygous (C) and homozygous (D and E) embryos harvested at E14.5. The mutant embryo shown in (D) was dead and arrested development by E12.5 (arrowhead points to the forelimb bud, which shows a characteristic E12 limb morphology, in contrast to the well formed digits in the heterozygous littermate in C). The mutant embryo shown in E was alive but had generalized edema (arrow). | ||||
| Copyright | This image is from Lan Y, Genesis 2011 May;49(5):419-22, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:172133 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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