All Phenotypes Anp32b<tm1Mak> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Anp32b^tm1Mak
targeted mutation 1, Tak Mak
MGI:5003050

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Anp32b^tm1Mak/Anp32b^tm1Mak	B6.129P2-Anp32b^tm1Mak	MGI:5003063
hm2	Anp32b^tm1Mak/Anp32b^tm1Mak	C.129P2(B6)-Anp32b^tm1Mak	MGI:5907168
hm3	Anp32b^tm1Mak/Anp32b^tm1Mak	FVB.129P2(B6)-Anp32b^tm1Mak	MGI:5907169
hm4	Anp32b^tm1Mak/Anp32b^tm1Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:5003062
cx5	Anp32b^tm1Mak/Anp32b^tm1Mak Anp32e^tm1Mak/Anp32e^tm1Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:5003066
cx6	Anp32a^tm1Mak/Anp32a^tm1Mak Anp32b^tm1Mak/Anp32b^tm1Mak Anp32e^tm1Mak/Anp32e^tm1Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:5003067
cx7	Anp32a^tm1Mak/Anp32a^tm1Mak Anp32b^tm1Mak/Anp32b^tm1Mak Anp32e^tm1Mak/Anp32e⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5003068
cx8	Anp32a^tm1Mak/Anp32a⁺ Anp32b^tm1Mak/Anp32b^tm1Mak Anp32e^tm1Mak/Anp32e^tm1Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:5003069
cx9	Anp32a^tm1Mak/Anp32a^tm1Mak Anp32b^tm1Mak/Anp32b⁺ Anp32e^tm1Mak/Anp32e^tm1Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:5003070
cx10	Anp32a^tm1Mak/Anp32a⁺ Anp32b^tm1Mak/Anp32b^tm1Mak Anp32e^tm1Mak/Anp32e⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5003071
cx11	Anp32a^tm1Mak/Anp32a⁺ Anp32b^tm1Mak/Anp32b^tm1Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:5003065
cx12	Anp32a^tm1Mak/Anp32a^tm1Mak Anp32b^tm1Mak/Anp32b^tm1Mak	involves: 129P2/OlaHsd * C57BL/6	MGI:5003064

Allelic Composition	Anp32b^tm1Mak/Anp32b^tm1Mak
Genetic Background	B6.129P2-Anp32b^tm1Mak

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32b^tm1Mak mutation (1 available); any Anp32b mutation (100 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:172042 )

• most mice die between E17.5 and the first 12 hours after birth

• Background Sensitivity: more mice die on a congenic C57BL/6 background compared with mice on a mixed background

• however, mice that are detected at 12 hours exhibit normal survival to adulthood

craniofacial

abnormal craniofacial morphology ( J:172042 )

• in some mice

cleft palate ( J:172042 )

• some mice exhibit palate closure defect compared with wild-type mice

nervous system

enlarged brain ventricles ( J:172042 )

• some mice exhibit overlarge brain ventricles compared with wild-type mice

respiratory system

primary atelectasis ( J:172042 )

• some mice never initiate breathing

hearing/vestibular/ear

abnormal inner ear morphology ( J:172042 )

• some mice exhibit expanded inner ear cavities compared with wild-type mice

digestive/alimentary system

cleft palate ( J:172042 )

• some mice exhibit palate closure defect compared with wild-type mice

growth/size/body

cleft palate ( J:172042 )

• some mice exhibit palate closure defect compared with wild-type mice

Allelic Composition	Anp32b^tm1Mak/Anp32b^tm1Mak
Genetic Background	C.129P2(B6)-Anp32b^tm1Mak

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32b^tm1Mak mutation (1 available); any Anp32b mutation (100 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:227403 )

• mice die prematurely but on no consistent cause with mice exhibiting a variety of illnesses (hydrocephalus, pulmonary adenoma, lymphoid aggregates on lungs, hyperplastic salivary gland, hamartoma of cardiomyocytes in the lung, segmental aplasia of the uterine horn, cardiomegaly, and dilated pancreatic ducts)

postnatal lethality, incomplete penetrance ( J:227403 )

• Background Sensitivity: fewer than mice on a congenic BALB/c background survive than expected although the decrease is not as severe as on a congenic C57BL/6J or FVB/N background due to the presence of modifier gene(s)

reproductive system

reproductive system phenotype ( J:227403 )

N	• surviving mice are fertile

homeostasis/metabolism

decreased circulating bilirubin level ( J:227403 )

decreased circulating cholesterol level ( J:227403 )

decreased circulating HDL cholesterol level ( J:227403 )

decreased circulating total protein level ( J:227403 )

increased incidence of tumors by chemical induction ( J:227403 )

• increased DMBA-induced cutaneous squamous cell carcinomas

• however, DMBA induced mammary gland, ovarian and lymphoid tumors are the same as in wild-type mice

neoplasm

increased incidence of tumors by chemical induction ( J:227403 )

• increased DMBA-induced cutaneous squamous cell carcinomas

• however, DMBA induced mammary gland, ovarian and lymphoid tumors are the same as in wild-type mice

growth/size/body

decreased body weight ( J:227403 )

Allelic Composition	Anp32b^tm1Mak/Anp32b^tm1Mak
Genetic Background	FVB.129P2(B6)-Anp32b^tm1Mak

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32b^tm1Mak mutation (1 available); any Anp32b mutation (100 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:227403 )

• Background Sensitivity: unlike when mice are congenic on an FVB/N background, very few mice congenic on a BALB/c background survive to P14

Allelic Composition	Anp32b^tm1Mak/Anp32b^tm1Mak
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32b^tm1Mak mutation (1 available); any Anp32b mutation (100 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Kyphosis in Anp32b^tm1Mak/Anp32b^tm1Mak mice

mortality/aging

premature death ( J:172042 )

• mice that survive to adulthood exhibit decreased life span

perinatal lethality, incomplete penetrance ( J:172042 )

• most mice die between E17.5 and the first 12 hours after birth

• Background Sensitivity: fewer mice die on a mixed background compared with mice on a congenic C57BL/6 background

• however, mice that are detected at 12 hours exhibit normal survival to adulthood

premature aging ( J:172042 )

• many mice exhibit early onset of aging symptoms (kyphosis and hepatocyte polyploidy) compared with wild-type mice

• however, mice do not exhibit alopecia

craniofacial

abnormal craniofacial morphology ( J:172042 )

• in some mice

cleft palate ( J:172042 )

• some mice exhibit palate closure defect compared with wild-type mice

nervous system

enlarged brain ventricles ( J:172042 )

• some mice exhibit overlarge brain ventricles compared with wild-type mice

respiratory system

primary atelectasis ( J:172042 )

• some mice never initiate breathing

cardiovascular system

hematoma ( J:172042 )

• in the liver, aortic arch, or umbilical artery of 3 of 8 mice at E17.5

• in the liver, aortic arch, or umbilical artery of 1 of 3 mouse at P1

growth/size/body

cleft palate ( J:172042 )

• some mice exhibit palate closure defect compared with wild-type mice

decreased body size ( J:172042 )

• in surviving mice

decreased body weight ( J:172042 )

• in surviving mice

hearing/vestibular/ear

abnormal inner ear morphology ( J:172042 )

• some mice exhibit expanded inner ear cavities compared with wild-type mice

renal/urinary system

hydroureter ( J:172042 )

• in 2 of 7 mice

cellular

cellular phenotype ( J:172042 )

N	• apoptosis and proliferation in thymocytes, primary and transformed mouse embryonic fibroblasts, and splenocytes are normal

polyploidy ( J:172042 )

• premature onset in the hepatocytes of many mice

digestive/alimentary system

cleft palate ( J:172042 )

• some mice exhibit palate closure defect compared with wild-type mice

megacolon ( J:172042 )

• in 2 of 7 mice

skeleton

kyphosis ( J:172042 )

• premature onset in many mice

Allelic Composition	Anp32b^tm1Mak/Anp32b^tm1Mak Anp32e^tm1Mak/Anp32e^tm1Mak
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32b^tm1Mak mutation (1 available); any Anp32b mutation (100 available)
Anp32e^tm1Mak mutation (1 available); any Anp32e mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:172042 )

• very few mice survive to weaning

Allelic Composition	Anp32a^tm1Mak/Anp32a^tm1Mak Anp32b^tm1Mak/Anp32b^tm1Mak Anp32e^tm1Mak/Anp32e^tm1Mak
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anp32a^tm1Mak mutation (1 available); any Anp32a mutation (56 available)
Anp32b^tm1Mak mutation (1 available); any Anp32b mutation (100 available)
Anp32e^tm1Mak mutation (1 available); any Anp32e mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:172042 )

• no mice survive to weaning

Allelic Composition	Anp32a^tm1Mak/Anp32a^tm1Mak Anp32b^tm1Mak/Anp32b^tm1Mak Anp32e^tm1Mak/Anp32e⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:172042 )

• no mice survive to weaning

Allelic Composition	Anp32a^tm1Mak/Anp32a⁺ Anp32b^tm1Mak/Anp32b^tm1Mak Anp32e^tm1Mak/Anp32e^tm1Mak
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:172042 )

• no mice survive to weaning

Allelic Composition	Anp32a^tm1Mak/Anp32a^tm1Mak Anp32b^tm1Mak/Anp32b⁺ Anp32e^tm1Mak/Anp32e^tm1Mak
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:172042 )

N	• expected number of mice survive to weaning

Allelic Composition	Anp32a^tm1Mak/Anp32a⁺ Anp32b^tm1Mak/Anp32b^tm1Mak Anp32e^tm1Mak/Anp32e⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:172042 )

• no mice survive to weaning

Allelic Composition	Anp32a^tm1Mak/Anp32a⁺ Anp32b^tm1Mak/Anp32b^tm1Mak
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:172042 )

• no mice survive to weaning

Allelic Composition	Anp32a^tm1Mak/Anp32a^tm1Mak Anp32b^tm1Mak/Anp32b^tm1Mak
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:172042 )

• no mice survive to weaning

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