Anp32b^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Anp32b^tm1Mak
• Name: acidic nuclear phosphoprotein 32 family member B; targeted mutation 1, Tak Mak
• MGI ID: MGI:5003050
• Gene: Anp32b Location: Chr4:46450926-46472657 bp, + strand Genetic Position: Chr4, 24.79 cM, cytoband B2
• Alliance: Anp32b^tm1Mak page

Kyphosis in Anp32b^tm1Mak/Anp32b^tm1Mak mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172042
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 2, 3, and 4 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:172042)

Generation of the Anp32b^tm1Mak allele

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Anp32b Mutation: 100 strains or lines available

Notes

Modifier gene(s) (unknown) linked to SNP rs6190775 on chromosome 11 alter(s) viability. J:227403

References

• Original: J:172042 Reilly PT, et al., Acidic nuclear phosphoprotein 32kDa (ANP32)B-deficient mouse reveals a hierarchy of ANP32 importance in mammalian development. Proc Natl Acad Sci U S A. 2011 Jun 2;108(25):10243-8
• All: 2 reference(s)