All Phenotypes Map2k7<tm1.2Twad> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Map2k7^tm1.2Twad
targeted mutation 1.2, Teiji Wada
MGI:4948951

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kras^tm4Tyj/Kras⁺ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad	B6.Cg-Kras^tm4Tyj Map2k7^tm1.1Twad/Map2k7^tm1.2Twad	MGI:4948962
cn2	Kras^tm4Tyj/Kras⁺ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:4948964
cn3	Kras^tm4Tyj/Kras⁺ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(Trp53)bSrn/0	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA	MGI:4948965
cn4	Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(MMTV-cre)4Mam/0 Tg(MMTV-Erbb2)1Pv/0	involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N	MGI:4948967
cn5	Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(MMTV-cre)4Mam/0	involves: 129P2/OlaHsd * C57BL/6 * FVB	MGI:4948966

Allelic Composition	Kras^tm4Tyj/Kras⁺ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad
Genetic Background	B6.Cg-Kras^tm4Tyj Map2k7^tm1.1Twad/Map2k7^tm1.2Twad

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (11 available); any Kras mutation (69 available)
Map2k7^tm1.1Twad mutation (0 available); any Map2k7 mutation (20 available)
Map2k7^tm1.2Twad mutation (0 available); any Map2k7 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:170904 )

neoplasm

increased lung tumor incidence ( J:170904 )

• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice

increased lung adenocarcinoma incidence ( J:170904 )

cellular

impaired DNA repair ( J:170904 )

• following adenovirus cre infection, mice exhibit impaired DNA damage response compared with control mice

homeostasis/metabolism

impaired DNA repair ( J:170904 )

• following adenovirus cre infection, mice exhibit impaired DNA damage response compared with control mice

respiratory system

increased lung tumor incidence ( J:170904 )

• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice

increased lung adenocarcinoma incidence ( J:170904 )

Allelic Composition	Kras^tm4Tyj/Kras⁺ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lung tumor incidence ( J:170904 )

• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice

• however, tumorigenesis is the same as in Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Kras^tm4Tyj/Kras⁺ mice

increased lung adenocarcinoma incidence ( J:170904 )

• following adenovirus cre infection, mice exhibit more adenocarcinomas than Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Kras^tm4Tyj/Kras⁺ mice

respiratory system

increased lung tumor incidence ( J:170904 )

• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice

• however, tumorigenesis is the same as in Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Kras^tm4Tyj/Kras⁺ mice

increased lung adenocarcinoma incidence ( J:170904 )

• following adenovirus cre infection, mice exhibit more adenocarcinomas than Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Kras^tm4Tyj/Kras⁺ mice

Allelic Composition	Kras^tm4Tyj/Kras⁺ Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(Trp53)bSrn/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:170904 )

N	• following adenovirus cre infection, mice exhibit the same tumor burden as in control mice

Allelic Composition	Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(MMTV-cre)4Mam/0 Tg(MMTV-Erbb2)1Pv/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CD-1 * DBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k7^tm1.1Twad mutation (0 available); any Map2k7 mutation (20 available)
Map2k7^tm1.2Twad mutation (0 available); any Map2k7 mutation (20 available)
Tg(MMTV-cre)4Mam mutation (2 available)
Tg(MMTV-Erbb2)1Pv mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:170904 )

• compared with control mice

neoplasm

increased mammary gland tumor incidence ( J:170904 )

• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice

increased mammary adenocarcinoma incidence ( J:170904 )

integument

increased mammary gland tumor incidence ( J:170904 )

• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice

increased mammary adenocarcinoma incidence ( J:170904 )

mammary gland hyperplasia ( J:170904 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:170904 )

• mammary gland tumor onset is earlier and tumor burden heavier than in Tg(MMTV-Erbb2)1Pv mice

increased mammary adenocarcinoma incidence ( J:170904 )

mammary gland hyperplasia ( J:170904 )

Allelic Composition	Map2k7^tm1.1Twad/Map2k7^tm1.2Twad Tg(MMTV-cre)4Mam/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:170904 )

N	• mice exhibit normal mammary gland formation throughout puberty

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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