All Phenotypes Crp<tm1Hjf> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Crp^tm1Hjf
targeted mutation 1, H J Fehling
MGI:4947397

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crp^tm1Hjf/Crp^tm1Hjf	C57BL/6-Crp^tm1Hjf	MGI:4947398
ht2	Crp^tm1Hjf/Crp⁺	C57BL/6-Crp^tm1Hjf	MGI:4947399
cx3	Apoe^tm1Unc/Apoe^tm1Unc Crp^tm1Hjf/Crp^tm1Hjf	B6.Cg-Crp^tm1Hjf Apoe^tm1Unc	MGI:4947400
cx4	Crp^tm1Hjf/Crp^tm1Hjf Ldlr^tm1Her/Ldlr^tm1Her	B6.Cg-Crp^tm1Hjf Ldlr^tm1Her	MGI:4947401

Allelic Composition	Crp^tm1Hjf/Crp^tm1Hjf
Genetic Background	C57BL/6-Crp^tm1Hjf

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crp^tm1Hjf mutation (1 available); any Crp mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating C-reactive protein level ( J:170409 )

• C-reactive protein serum levels are undetectable unlike in wild-type mice

immune system

decreased circulating C-reactive protein level ( J:170409 )

• C-reactive protein serum levels are undetectable unlike in wild-type mice

Allelic Composition	Crp^tm1Hjf/Crp⁺
Genetic Background	C57BL/6-Crp^tm1Hjf

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crp^tm1Hjf mutation (1 available); any Crp mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating C-reactive protein level ( J:170409 )

• C-reactive protein serum levels are reduced by half compared to in wild-type mice

immune system

decreased circulating C-reactive protein level ( J:170409 )

• C-reactive protein serum levels are reduced by half compared to in wild-type mice

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Crp^tm1Hjf/Crp^tm1Hjf
Genetic Background	B6.Cg-Crp^tm1Hjf Apoe^tm1Unc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (34 available); any Apoe mutation (162 available)
Crp^tm1Hjf mutation (1 available); any Crp mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:170409 )

• in female mice fed a low-fat, semi-synthetic diet at 16 weeks of age

increased circulating HDL cholesterol level ( J:170409 )

• in female mice fed a low-fat, semi-synthetic diet at 16 weeks of age

decreased circulating triglyceride level ( J:170409 )

• in female mice fed a low-fat, semi-synthetic diet at 12 weeks of age

cardiovascular system

increased susceptibility to atherosclerosis ( J:170409 )

• at 12 weeks of age, female mice fed a low-fat, semi-synthetic diet exhibit an increase in susceptibility to atherosclerosis in the aortic root compared with Apoe^tm1Unc homozygotes

• at 16 weeks of age, male mice fed a low-fat, semi-synthetic diet exhibit an increase in susceptibility to atherosclerosis in the aortic root compared with Apoe^tm1Unc homozygotes

Allelic Composition	Crp^tm1Hjf/Crp^tm1Hjf Ldlr^tm1Her/Ldlr^tm1Her
Genetic Background	B6.Cg-Crp^tm1Hjf Ldlr^tm1Her

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crp^tm1Hjf mutation (1 available); any Crp mutation (20 available)
Ldlr^tm1Her mutation (21 available); any Ldlr mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating LDL cholesterol level ( J:170409 )

• in male mice at 20 weeks

decreased circulating VLDL cholesterol level ( J:170409 )

• in male mice at 20 weeks

increased circulating cholesterol level ( J:170409 )

• in male mice at 20 weeks

increased circulating triglyceride level ( J:170409 )

• in male mice at 20 weeks

cardiovascular system

atherosclerotic lesions ( J:170409 )

• female mice exhibit an increase in macrophage content in lesions compared with Ldlr^tm1Her homozygotes

• however, lesion size and susceptibility do not differ from Ldlr^tm1Her homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24