All Phenotypes Tg(Fadd/EGFP)#Jizh MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Fadd/EGFP)#Jizh
transgene insertion, Jianke Zhang
MGI:4943162

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fadd^tm1Wnt/Fadd^tm1Wnt Tg(Fadd/EGFP)#Jizh/? Tg(Lck-cre)1Cwi/?	involves: 129S4/SvJae	MGI:4943254
cn2	Fadd^tm1Wnt/Fadd^tm1Wnt Tg(Fadd/EGFP)#Jizh/? Tg(Mx1-cre)1Cgn/?	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:4943260
cn3	Fadd^tm1Wnt/Fadd^tm1Wnt Tg(Fadd/EGFP)#Jizh/? Tg(Cd4-cre)1Cwi/?	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:4943257

Allelic Composition	Fadd^tm1Wnt/Fadd^tm1Wnt Tg(Fadd/EGFP)#Jizh/? Tg(Lck-cre)1Cwi/?
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fadd^tm1Wnt mutation (0 available); any Fadd mutation (19 available)
Tg(Fadd/EGFP)#Jizh mutation (0 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased sensitivity to induced cell death ( J:113207 )

• anti-Fas antibody fails to induce cell death in T-cells as it does in controls

• resistant to FasL induced cell death

immune system

immune system phenotype ( J:113207 )

N	• thymus, spleen, and lymph nodes all appear to be normal

increased B cell number ( J:113207 )

• peripheral B-cells are increased in number

decreased activated T cell number ( J:113207 )

• TCR activation of T-cells is reduced

decreased single-positive T cell number ( J:113207 )

• both CD4+ and CD8+ peripheral T-cells are reduced in number

• peripheral T-cells divide less efficiently when transplanted to Rag1 deficient mice

hematopoietic system

increased B cell number ( J:113207 )

• peripheral B-cells are increased in number

decreased activated T cell number ( J:113207 )

• TCR activation of T-cells is reduced

decreased single-positive T cell number ( J:113207 )

• both CD4+ and CD8+ peripheral T-cells are reduced in number

• peripheral T-cells divide less efficiently when transplanted to Rag1 deficient mice

Allelic Composition	Fadd^tm1Wnt/Fadd^tm1Wnt Tg(Fadd/EGFP)#Jizh/? Tg(Mx1-cre)1Cgn/?
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fadd^tm1Wnt mutation (0 available); any Fadd mutation (19 available)
Tg(Fadd/EGFP)#Jizh mutation (0 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:168722 )

• cellularity is reduced at 4 days after induction with poly(I:C)

• cell numbers continue to drop over a 3 month period

abnormal bone marrow cell morphology/development ( J:168722 )

• bone marrow progenitor cells with a decreased tendency to develop into macrophage and dendritic cells after induction with poly(I:C)

• progenitors have reduced in vitro colony forming ability

decreased bone marrow cell number ( J:168722 )

• cellularity of bone marrow is reduced at 4 days after induction with poly(I:C)

• cell numbers continue to drop over a 3 month period

abnormal erythrocyte morphology ( J:168722 )

• RBC volume in peripheral blood is significantly reduced up to 6 days after induction with poly(I:C)

spleen hypoplasia ( J:168722 )

• cellularity is reduced at 4 days after induction with poly(I:C) but not significantly

• cell numbers continue to drop over a 3 month period

immune system

thymus hypoplasia ( J:168722 )

• cellularity is reduced at 4 days after induction with poly(I:C)

• cell numbers continue to drop over a 3 month period

spleen hypoplasia ( J:168722 )

• cellularity is reduced at 4 days after induction with poly(I:C) but not significantly

• cell numbers continue to drop over a 3 month period

endocrine/exocrine glands

thymus hypoplasia ( J:168722 )

• cellularity is reduced at 4 days after induction with poly(I:C)

• cell numbers continue to drop over a 3 month period

Allelic Composition	Fadd^tm1Wnt/Fadd^tm1Wnt Tg(Fadd/EGFP)#Jizh/? Tg(Cd4-cre)1Cwi/?
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fadd^tm1Wnt mutation (0 available); any Fadd mutation (19 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(Fadd/EGFP)#Jizh mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased sensitivity to induced cell death ( J:113207 )

• anti-Fas antibody fails to induce cell death in T-cells as it does in controls

• resistant to FasL induced cell death

immune system

immune system phenotype ( J:113207 )

N	• thymus, spleen, and lymph nodes all appear to be normal

increased B cell number ( J:113207 )

• peripheral B-cells are increased in number

decreased activated T cell number ( J:113207 )

• TCR activation of T-cells is reduced

decreased single-positive T cell number ( J:113207 )

• both CD4+ and CD8+ peripheral T-cells are reduced in number

• peripheral T-cells divide less efficiently when transplanted to Rag1 deficient mice

hematopoietic system

increased B cell number ( J:113207 )

• peripheral B-cells are increased in number

decreased activated T cell number ( J:113207 )

• TCR activation of T-cells is reduced

decreased single-positive T cell number ( J:113207 )

• both CD4+ and CD8+ peripheral T-cells are reduced in number

• peripheral T-cells divide less efficiently when transplanted to Rag1 deficient mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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