Phenotypes associated with this allele

• Allele Symbol: Tg(Ncr1-icre)265Sxl
• Allele Name: transgene insertion 265, Veronika Sexl
• Allele ID: MGI:4941472
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(CAG-STAT5B*N642H,-EGFP)Biat/Gt(ROSA)26Sor^tm1(CAG-STAT5B*N642H,-EGFP)Biat Tg(Ncr1-icre)265Sxl/0	involves: C57BL/6N * C57BL/6NTac	MGI:8259757

Genotype
MGI:8259757

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-STAT5B*N642H,-EGFP)Biat}/Gt(ROSA)26Sor^{tm1(CAG-STAT5B*N642H,-EGFP)Biat}; Tg(Ncr1-icre)265Sxl/0
• Genetic Background: involves: C57BL/6N * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal NK cell morphology ( J:350923 )

• levels of granzyme B and perforin are enhanced in NK cells

increased NK cell number ( J:350923 )

• mice show increased NK-cell numbers in blood, spleen, and bone marrow

• an expansion of NK cells is already detectable in the blood as early as 4 weeks of age

• NK cells are the predominantly expanded cell type in the spleen of 5 of 8 diseased mice

increased mature NK cell number ( J:350923 )

• mice show more mature NK cells in the bone morrow and spleen than controls

abnormal NK cell physiology ( J:350923 )

• splenic NK cells show reduced apoptosis ex vivo

immune system

abnormal NK cell morphology ( J:350923 )

• levels of granzyme B and perforin are enhanced in NK cells

increased NK cell number ( J:350923 )

• mice show increased NK-cell numbers in blood, spleen, and bone marrow

• an expansion of NK cells is already detectable in the blood as early as 4 weeks of age

• NK cells are the predominantly expanded cell type in the spleen of 5 of 8 diseased mice

increased mature NK cell number ( J:350923 )

• mice show more mature NK cells in the bone morrow and spleen than controls

abnormal NK cell physiology ( J:350923 )

• splenic NK cells show reduced apoptosis ex vivo

neoplasm

increased leukemia incidence ( J:350923 )

• 8 of 24 (approximately 33%) of mice develop NK-cell leukemia within 17 months; mice display an NK-large granular lymphocytic leukemia (NK-LGLL) that progresses to an aggressive leukemia with age, suffer from weight loss, splenomegaly, and expansion of EGFP+ cells in various organs, including spleen, liver, bone marrow, and blood

• NK cells are the predominantly expanded cell type in the spleen of 5 of 8 diseased mice

• transplantation of mutant splenic cells into immunodeficient NOD scid gamma (NSG) recipients, results in initiation of a fast-progressing leukemia in all recipient mice, with weight loss, hepatosplenomegaly, anemia and multiple organ infiltration and a leukemia with NK-cell phenotype is seen in about 70% of recipients

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
aggressive NK-cell leukemia		DOID:1035		J:350923