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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rag2tm2.1Desi
targeted mutation 2.1, Stephen Desiderio
MGI:4941316
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Rag2tm2.1Desi/Rag2tm2.1Desi
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:4941323


Genotype
MGI:4941323
cx1
Allelic
Composition		 Rag2tm2.1Desi/Rag2tm2.1Desi
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm2.1Desi mutation (0 available); any Rag2 mutation (115 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:168974 )
• in half of mice by 20 weeks, similar to in Trp53tm1Tyj homozygotes

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:168974 )
• in half of mice by 20 weeks, similar to in Trp53tm1Tyj homozygotes

immune system
increased T cell derived lymphoma incidence ( J:168974 )
• in half of mice by 20 weeks, similar to in Trp53tm1Tyj homozygotes

hematopoietic system
increased T cell derived lymphoma incidence ( J:168974 )
• in half of mice by 20 weeks, similar to in Trp53tm1Tyj homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory