Phenotypes associated with this allele

• Allele Symbol: Tg(CD2-Lmo2)#Thr
• Allele Name: transgene insertion, Terence H Rabbitts
• Allele ID: MGI:4889196
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dnm2^M1/Dnm2^+ Tg(CD2-Lmo2)#Thr/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:8393462
tg2	Tg(CD2-Lmo2)#Thr/0	involves: C57BL/6 * CBA	MGI:4889198

Genotype
MGI:8393462

cx1

• Allelic Composition: Dnm2^M1/Dnm2⁺; Tg(CD2-Lmo2)#Thr/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased double-negative T cell number ( J:236123 )

• more DN1, DN2 and DN3 immature T cells at age 12 and 15 months

immune system

increased double-negative T cell number ( J:236123 )

• more DN1, DN2 and DN3 immature T cells at age 12 and 15 months

neoplasm

increased T cell acute lymphoblastic leukemia incidence ( J:236123 )

• accelerated onset and increased penetrance

• T-ALL arising from more immature T cells

• more leukemic stem cells

Genotype
MGI:4889198

tg2

• Allelic Composition: Tg(CD2-Lmo2)#Thr/0
• Genetic Background: involves: C57BL/6 * CBA

mortality/aging

premature death ( J:102058 )

• mice die from acute lymphoblastic leukemia unlike wild-type mice

immune system

enlarged thymus ( J:102058 )

enlarged spleen ( J:102058 )

neoplasm

increased acute lymphoblastic leukemia incidence ( J:102058 )

• mice die from acute lymphoblastic leukemia unlike wild-type mice

hematopoietic system

enlarged thymus ( J:102058 )

enlarged spleen ( J:102058 )

endocrine/exocrine glands

enlarged thymus ( J:102058 )

growth/size/body

enlarged spleen ( J:102058 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia		DOID:9952	OMIM:247640 OMIM:613065	J:102058