Dnm2^M1
Chemically induced Allele Detail

Summary

• Symbol: Dnm2^M1
• Name: dynamin 2; mutation 1
• MGI ID: MGI:8393445
• Synonyms: Dnm2^V265G
• Gene: Dnm2 Location: Chr9:21336204-21419055 bp, + strand Genetic Position: Chr9, 7.79 cM
• Alliance: Dnm2^M1 page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Chemically induced (ENU) (Dominant negative)
• Mutation: Single point mutation
• Mutation details:

  ENU mutagenesis induced a T-to-G mutation in the sequence encoding the Ras-like GTPase domain, changing valine codon 235 (GTT) to glycine (GGT) (p.V235G). The mutation accelerates T-cell acute lymphoblastic leukemia (T-ALL) onset in a T-ALL model mouse. (J:236123)

• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnm2 Mutation: 101 strains or lines available

References

• Original: J:236123 Tremblay CS, et al., Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling. Leukemia. 2016 Oct;30(10):1993-2001
• All: 1 reference(s)