Phenotypes associated with this allele

• Allele Symbol: Dnm2^M1
• Allele Name: mutation 1
• Allele ID: MGI:8393445
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnm2^M1/Dnm2^M1	involves: C57BL/6J	MGI:8393459
ht2	Dnm2^M1/Dnm2^+	involves: C57BL/6J	MGI:8393457
cx3	Dnm2^M1/Dnm2^+ Tg(CD2-Lmo2)#Thr/0	involves: C57BL/6 * C57BL/6J * CBA	MGI:8393462

Genotype
MGI:8393459

hm1

• Allelic Composition: Dnm2^M1/Dnm2^M1
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning ( J:236123 )

• embryos die before E8.5

Genotype
MGI:8393457

ht2

• Allelic Composition: Dnm2^M1/Dnm2⁺
• Genetic Background: involves: C57BL/6J

hematopoietic system

microcytic anemia ( J:236123 )

neoplasm

neoplasm ( J:236123 )

N • no incidence of T-cell acute lymphoblastic leukemia (T-ALL)

Genotype
MGI:8393462

cx3

• Allelic Composition: Dnm2^M1/Dnm2⁺; Tg(CD2-Lmo2)#Thr/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

hematopoietic system

increased double-negative T cell number ( J:236123 )

• more DN1, DN2 and DN3 immature T cells at age 12 and 15 months

immune system

increased double-negative T cell number ( J:236123 )

• more DN1, DN2 and DN3 immature T cells at age 12 and 15 months

neoplasm

increased T cell acute lymphoblastic leukemia incidence ( J:236123 )

• accelerated onset and increased penetrance

• T-ALL arising from more immature T cells

• more leukemic stem cells