Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relnrl mutation
(3 available);
any
Reln mutation
(209 available)
Tg(Mbp-MAPT/lacZ)#aCaw mutation
(0 available)
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nervous system
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• thalamocortical axons fail to extend beneath the cortical plate and grow obliquely across it unlike in wild-type mice
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cellular
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• thalamocortical axons fail to extend beneath the cortical plate and grow obliquely across it unlike in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx2wndr mutation
(0 available);
any
Emx2 mutation
(23 available)
Tg(Mbp-MAPT/lacZ)#aCaw mutation
(0 available)
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mortality/aging
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• mice die within a few hours of birth
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nervous system
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• thalamocortical axons exhibit severe ventral misrouting near the diencephalon-telencephalon boundary on the ventral surface compared with wild-type mice
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renal/urinary system
cellular
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• thalamocortical axons exhibit severe ventral misrouting near the diencephalon-telencephalon boundary on the ventral surface compared with wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mbp-MAPT/lacZ)#aCaw mutation
(0 available)
Trip11m1Mawa mutation
(0 available);
any
Trip11 mutation
(99 available)
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mortality/aging
nervous system
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N |
• mice exhibit normal thalamocortical axons
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growth/size/body
limbs/digits/tail
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif20bmagoo mutation
(0 available);
any
Kif20b mutation
(69 available)
Tg(Mbp-MAPT/lacZ)#aCaw mutation
(0 available)
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mortality/aging
nervous system
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• mice exhibit occasional ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
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• mice exhibit occasional ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
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vision/eye
craniofacial
limbs/digits/tail
digestive/alimentary system
cellular
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• mice exhibit occasional ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
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growth/size/body
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
nervous system
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• thalamocortical axons exhibit fascicles to ectopia outside pia unlike in wild-type mice
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• the forebrain has a cobblestone surface unlike in wild-type mice
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limbs/digits/tail
cellular
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• thalamocortical axons exhibit fascicles to ectopia outside pia unlike in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hspa5baffled mutation
(0 available);
any
Hspa5 mutation
(38 available)
Tg(Mbp-MAPT/lacZ)#aCaw mutation
(0 available)
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mortality/aging
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• mutants collected after birth died within hours (100%; 15 of 15)
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nervous system
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• the thalamocortical axons are disorganized in the ventral telencephalon with some stalled at the corticostriatal boundary unlike in wild-type mice
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• some thalamocortical axons are overfasciculated and stalling compared to in wild-type mice
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• the thalamocortical axons are disorganized in the ventral telencephalon with some stalled at the corticostriatal boundary unlike in wild-type mice
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• the intermediate zone contains large swollen bundles of axon compared with wild-type mice
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renal/urinary system
respiratory system
cardiovascular system
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• under the nose in 20 of 21 mice
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craniofacial
digestive/alimentary system
cellular
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• the thalamocortical axons are disorganized in the ventral telencephalon with some stalled at the corticostriatal boundary unlike in wild-type mice
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• some thalamocortical axons are overfasciculated and stalling compared to in wild-type mice
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growth/size/body
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
nervous system
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• some mice exhibit ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
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• some mice exhibit ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
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vision/eye
craniofacial
digestive/alimentary system
cellular
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• some mice exhibit ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
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growth/size/body
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
nervous system
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• thalamocortical axons exhibit overfasciculation and stalling compared to in wild-type mice
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cellular
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• thalamocortical axons exhibit overfasciculation and stalling compared to in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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normal phenotype
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• mice are viable and fertile, with no detectable abnormal phenotypes in brain morphology or thalamacortical axon patterning at birth
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Analysis Tools