Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Mbp-MAPT/lacZ)#aCaw transgene insertion #a, Christopher A Walsh MGI:4888711 |
||||||||||||||||||||||||||||||||||||||||
| Summary |
9 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• thalamocortical axons fail to extend beneath the cortical plate and grow obliquely across it unlike in wild-type mice
|
|
• thalamocortical axons fail to extend beneath the cortical plate and grow obliquely across it unlike in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice die within a few hours of birth
|
|
• thalamocortical axons exhibit severe ventral misrouting near the diencephalon-telencephalon boundary on the ventral surface compared with wild-type mice
|
|
• small and misshapen
|
|
• small and misshapen
|
|
• thalamocortical axons exhibit severe ventral misrouting near the diencephalon-telencephalon boundary on the ventral surface compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal thalamocortical axons
|
|
• slightly small
|
|
• slightly small
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit occasional ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
|
|
• slightly small
|
|
• mice exhibit occasional ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
|
|
• in some mice
|
|
• in some mice
|
|
• in 38 of 46 mice
|
|
• in 38 of 46 mice
|
|
• in 10 of 42 mice
|
|
• in 13% of mice
|
|
• in 10 of 42 mice
|
|
• mice exhibit occasional ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
|
|
• in 10 of 42 mice
|
|
• small head
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• thalamocortical axons exhibit fascicles to ectopia outside pia unlike in wild-type mice
|
|
• the forebrain has a cobblestone surface unlike in wild-type mice
|
|
• stunted
|
|
• thalamocortical axons exhibit fascicles to ectopia outside pia unlike in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mutants collected after birth died within hours (100%; 15 of 15)
|
|
• some thalamocortical axons are overfasciculated and stalling compared to in wild-type mice
|
|
• the thalamocortical axons are disorganized in the ventral telencephalon with some stalled at the corticostriatal boundary unlike in wild-type mice
|
|
• the thalamocortical axons are disorganized in the ventral telencephalon with some stalled at the corticostriatal boundary unlike in wild-type mice
|
|
• the intermediate zone contains large swollen bundles of axon compared with wild-type mice
|
|
• round
|
|
• slightly small
|
|
• slightly small
|
|
• some thalamocortical axons are overfasciculated and stalling compared to in wild-type mice
|
|
• the thalamocortical axons are disorganized in the ventral telencephalon with some stalled at the corticostriatal boundary unlike in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• some mice exhibit ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
|
|
• some mice exhibit ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
|
|
• some mice exhibit ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• thalamocortical axons exhibit overfasciculation and stalling compared to in wild-type mice
|
|
• thalamocortical axons exhibit overfasciculation and stalling compared to in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice are viable and fertile, with no detectable abnormal phenotypes in brain morphology or thalamacortical axon patterning at birth
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 09/30/2025 MGI 6.24 |
|
|
|
||
