Hspa5^baffled
Chemically induced Allele Detail

Summary

• Symbol: Hspa5^baffled
• Name: heat shock protein 5; baffled
• MGI ID: MGI:4888745
• Synonyms: ND58
• Gene: Hspa5 Location: Chr2:34662102-34666541 bp, + strand Genetic Position: Chr2, 22.94 cM
• Alliance: Hspa5^baffled page

Mutation origin

• Strain of Origin: BALB/c x C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU induced an A to G transition in exon 1 that results in the amino acid substitution of glycine for glutamic acid at position 26 (E26G). This mutation alters a conserved hydrophilic motif that forms the N-terminus after the signal peptidase cleavage. Expression level and localization are not disrupted. This allele is hypomorphic. (J:191772)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspa5 Mutation: 38 strains or lines available

Notes

Originally generated from male mice expressing Tg(Mbp-MAPT/lacZ)#Caw.

References

• Original: J:168258 Dwyer ND, et al., A forward genetic screen with a thalamocortical axon reporter mouse yields novel neurodevelopment mutants and a distinct emx2 mutant phenotype. Neural Dev. 2011;6:3
• All: 2 reference(s)