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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CAG-Otx2,-GFP)21Asim
transgene insertion 21, Antonio Simeone
MGI:4887448
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Tg(CAG-Otx2,-GFP)21Asim/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:4887466


Genotype
MGI:4887466
cn1
Allelic
Composition
Gt(ROSA)26Sortm1.1(Otx2)Daac/Gt(ROSA)26Sortm1.1(Otx2)Daac
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Tg(CAG-Otx2,-GFP)21Asim/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.1(Otx2)Daac mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Slc6a3tm1.1(cre)Bkmn mutation (3 available); any Slc6a3 mutation (66 available)
Tg(CAG-Otx2,-GFP)21Asim mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• MPTP-treated mice exhibit increased number of tyrosine hydroxylase (TH)+ neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) compared with Slc6a3tm1.1(cre)Bkmn heterozygotes
• mice exhibit a reduction in the percentage of Kcnj6 (Girk2)+ or glyco-Slc6a3 (DAT)+ and tyrosine hydroxylase (TH)+ neurons in the ventral tegmental area (VTA) compared with wild-type mice

homeostasis/metabolism
• MPTP-treated mice exhibit increased number of tyrosine hydroxylase (TH)+ neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) compared with Slc6a3tm1.1(cre)Bkmn heterozygotes

cellular
• MPTP-treated mice exhibit increased number of tyrosine hydroxylase (TH)+ neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) compared with Slc6a3tm1.1(cre)Bkmn heterozygotes





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory