Tg(CAG-Otx2,-GFP)21Asim
Transgene Detail

Summary

• Symbol: Tg(CAG-Otx2,-GFP)21Asim
• Name: transgene insertion 21, Antonio Simeone
• MGI ID: MGI:4887448
• Synonyms: Tg(CAG-stop-Otx2,-GFP)21Asim, tOtx2^bov
• Transgene: Tg(CAG-Otx2,-GFP)21Asim Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Tg(CAG-Otx2,-GFP)21Asim page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:143341
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Otx2,-GFP)21Asim expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Otx2 (MGI:97451)

• Mutation details: The transgene, which contained a CAG promoter, floxed neo/STOP cassette, the Otx2 cDNA, and an IRES-GFP, was inserted using the Vectorette System (Sigma) 51 kb downstream of Isg20 and 111 kb upstream of Acan on chromosome 7 D2. No line number was given. (J:143341)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:143341 Omodei D, et al., Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon. Development. 2008 Oct;135(20):3459-70
• All: 4 reference(s)