Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnpt1tm1Teit mutation
(0 available);
any
Pnpt1 mutation
(40 available)
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normal phenotype
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• mice are viable and fertile
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnpt1tm1Teit mutation
(0 available);
any
Pnpt1 mutation
(40 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation
(6 available);
any
Speer6-ps1 mutation
(4 available)
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cellular
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• mitochondria in liver cells exhibit disordered circular and smooth IM cristae compared to in wild-type cells
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• mitochondria in liver cells exhibit inefficient mtRNA precursor processing and impaired RNA import compared to in wild-type cells
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• mitochondria in liver cells exhibit a 1.5- to 2-fold decrease in activity of Complex IV and Complexes II+III+IV compared to in wild-type cells
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