Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation
(11 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Slc17a6tm1.1Thna mutation
(0 available);
any
Slc17a6 mutation
(59 available)
Slc6a3tm1(cre)Xz mutation
(2 available);
any
Slc6a3 mutation
(66 available)
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nervous system
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• only a minority of dopaminergic projections remain intake
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• YFP+ dopamine neurons fail to exhibit glutamatergic excitatory postsynaptic currents (EPSCs) unlike control cells
• at P9 to P10, mice exhibit a reduction in glutamatergic with fewer neurons responding to ventral tegmental area stimulation compared with similarly treated control cells
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behavior/neurological
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• cocaine-treated mice exhibit less locomotor activity compared with control mice
• however, cocaine-treated mice exhibit conditioned place preference
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm2Arbr mutation
(1 available);
any
Mapt mutation
(428 available)
Shox2tm1.1(cre)Oki mutation
(0 available);
any
Shox2 mutation
(19 available)
Slc17a6tm1.1Thna mutation
(0 available);
any
Slc17a6 mutation
(59 available)
Slc17a6tm1.2Edw mutation
(0 available);
any
Slc17a6 mutation
(59 available)
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nervous system
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• frequencies of locomotor activity induced in isolated spinal cords increase with increasing NMDA concentrations, but are significantly lower than those observed in control spinal cords
• locomotor burst duration increases but duty cycle is not changed in mutant preparations (increased interburst interval)
• coefficients of variation of main locomotor parameters (cycle period, burst duration, amplitude, duty cycle) are increased compared to controls
• spinal cords from mutants display lower drug-evoked and stimulus-evoked locomotor frequencies
• flexor-extensor coupling is not significantly changed at any locomotor frequency
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrptm2(HBEGF)Rpa mutation
(1 available);
any
Agrp mutation
(18 available)
Slc17a6tm1.1Thna mutation
(0 available);
any
Slc17a6 mutation
(59 available)
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growth/size/body
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• diphtheria-treated mice injected with a virus expressing a AAV1-CreGFP into the nucleus tractus solitaries or parabrachial nucleus prevents starvation induced by AgRP neuron ablation unlike in control mice
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• mice injected with a virus expressing a AAV1-CreGFP into the parabrachial nucleus without ablation of AgRP neurons
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behavior/neurological
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• mice injected with a virus expressing a AAV1-CreGFP into the parabrachial nucleus whether treated with diphtheria or not
• in diphtheria treated mice bilaterally with a virus expressing a AAV1-CreGFP into the nucleus tractus solitaries
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Analysis Tools