About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cxcr4tm3.1Yzo
targeted mutation 3.1, Yong-Rui Zou
MGI:4878934
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cxcr4tm3.1Yzo/Cxcr4tm3.1Yzo Not Specified MGI:4878989
cn2
 		Cxcr4tm2Yzo/Cxcr4tm3.1Yzo
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd MGI:4878990


Genotype
MGI:4878989
hm1
Allelic
Composition		 Cxcr4tm3.1Yzo/Cxcr4tm3.1Yzo
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr4tm3.1Yzo mutation (0 available); any Cxcr4 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:167314 )
• mice are present in Mendelian ratios until E18.5

immune system
impaired myelopoiesis ( J:167314 )
• in the bone marrow
abnormal B cell physiology ( J:167314 )
• pro-B cells exhibit impaired chemotactic response towards CXCL12 compared with wild-type cells
• however, CXCL12-stimulated VCAM1 binding is normal

cardiovascular system
abnormal blood vessel morphology ( J:167314 )
• mice lack large vessels in the gastrointestinal area compared with wild-type mice

nervous system
abnormal cerebellum external granule cell layer morphology ( J:167314 )
• mice exhibit displaced cells of the external granule layer in the cerebellum compared with wild-type mice

hematopoietic system
impaired myelopoiesis ( J:167314 )
• in the bone marrow
abnormal B cell physiology ( J:167314 )
• pro-B cells exhibit impaired chemotactic response towards CXCL12 compared with wild-type cells
• however, CXCL12-stimulated VCAM1 binding is normal




Genotype
MGI:4878990
cn2
Allelic
Composition		 Cxcr4tm2Yzo/Cxcr4tm3.1Yzo
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Cxcr4tm2Yzo mutation (1 available); any Cxcr4 mutation (46 available)
Cxcr4tm3.1Yzo mutation (0 available); any Cxcr4 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:167314 )
• B cell precursors are released into the peripheral blood and reduced in the spleen unlike in wild-type mice but not as severely as in Cxcr4tm1Yzo homozygotes

immune system
abnormal B cell differentiation ( J:167314 )
• B cell precursors are released into the peripheral blood and reduced in the spleen unlike in wild-type mice but not as severely as in Cxcr4tm1Yzo homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory