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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hes1tm1.1Frad
targeted mutation 1.1, Freddy Radtke
MGI:4868726
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Hes1tm1.1Frad/Hes1tm1.1Frad
Tg(Mx1-cre)1Cgn/0 		involves: 129S4/SvJaeSor * C57BL/6 * CBA MGI:4868732
cn2
 		Hes1tm1.1Frad/Hes1tm1.1Frad
Tg(Lck-cre)1Cwi/0 		involves: C57BL/6 MGI:4868731
cn3
 		Hes1tm1.1Frad/Hes1tm1.1Frad
Tg(Mx1-cre)1Cgn/0 		involves: C57BL/6 * CBA MGI:4868728
cn4
 		Hes1tm1.1Frad/Hes1tm1.1Frad
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:4868730


Genotype
MGI:4868732
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+
Hes1tm1.1Frad/Hes1tm1.1Frad
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Notch1)Dam mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Hes1tm1.1Frad mutation (0 available); any Hes1 mutation (21 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased lymphoma incidence ( J:167000 )
• mutant bone marrow transplanted chimeras survive to 250 days after pI-pC treatment
• decreased numbers of CD45.2+eGFP+ DP leukemic cells in the mutant bone marrow transplanted chimeras at 3 and 12 weeks
• CD45.2+eGFP+ DP leukemic cells disappear by 24 weeks

immune system
decreased B cell number ( J:167000 )
• decreased B220+ B cell numbers

hematopoietic system
decreased B cell number ( J:167000 )
• decreased B220+ B cell numbers




Genotype
MGI:4868731
cn2
Allelic
Composition		 Hes1tm1.1Frad/Hes1tm1.1Frad
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes1tm1.1Frad mutation (0 available); any Hes1 mutation (21 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:167000 )
N
• normal T cell development




Genotype
MGI:4868728
cn3
Allelic
Composition		 Hes1tm1.1Frad/Hes1tm1.1Frad
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes1tm1.1Frad mutation (0 available); any Hes1 mutation (21 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:167000 )
N
• normal hematopoietic stem cell maintenance and self-renewal in steady state homeostasis as well as under stringent challenge situations
• normal development of splenic marginal zone B cells when tested in competitive mixed bone marrow chimeras
thymus hypoplasia ( J:167000 )
• reduced total, DP, CD4 SP and CD8 SP cell numbers in the thymus when tested in competitive mixed bone marrow chimeras
• dramatic failure of bone marrow progenitors to contribute to thymus cellularity (total and DP) in competitive mixed bone marrow chimeras
• normal thymic B cells
• normal cell death and proliferative capacity
increased immature B cell number ( J:167000 )
• increased immature B cells after competitive intrathymic transfer
abnormal T cell differentiation ( J:167000 )
• intrathymicly transferred Lin- bone marrow progenitors develop into T cells with markedly slower kinetics compared to control cells
• failure of Lin- bone marrow progenitors to contribute to thymus cellularity at 16 days after competitive intrathymic transfer
• normal percentage of DN, DP, CD4+, and CD8+ SP thymocyte subpopulations at 21 days after transfer
decreased DN1 thymic pro-T cell number ( J:167000 )
• reduced absolute cell numbers when tested in competitive mixed bone marrow chimeras
decreased DN2 thymocyte number ( J:167000 )
• reduced absolute cell numbers when tested in competitive mixed bone marrow chimeras
decreased DN3 thymocyte number ( J:167000 )
• reduced absolute cell numbers when tested in competitive mixed bone marrow chimeras
decreased DN4 thymocyte number ( J:167000 )
• reduced absolute cell numbers when tested in competitive mixed bone marrow chimeras
increased DN1 thymic pro-T cell number ( J:167000 )
• increased relative numbers of DN1 compared to the corresponding control at 16 days after intrathymic transfer of Lin- bone marrow progenitors
decreased double-positive T cell number ( J:167000 )
• reduced numbers of DP thymocytes after competitive intrathymic transfer
decreased gamma-delta T cell number ( J:167000 )
• reduced frequency and absolute numbers of gamma-delta T cells when tested in competitive mixed bone marrow chimeras

immune system
thymus hypoplasia ( J:167000 )
• reduced total, DP, CD4 SP and CD8 SP cell numbers in the thymus when tested in competitive mixed bone marrow chimeras
• dramatic failure of bone marrow progenitors to contribute to thymus cellularity (total and DP) in competitive mixed bone marrow chimeras
• normal thymic B cells
• normal cell death and proliferative capacity
increased immature B cell number ( J:167000 )
• increased immature B cells after competitive intrathymic transfer
abnormal T cell differentiation ( J:167000 )
• intrathymicly transferred Lin- bone marrow progenitors develop into T cells with markedly slower kinetics compared to control cells
• failure of Lin- bone marrow progenitors to contribute to thymus cellularity at 16 days after competitive intrathymic transfer
• normal percentage of DN, DP, CD4+, and CD8+ SP thymocyte subpopulations at 21 days after transfer
decreased DN1 thymic pro-T cell number ( J:167000 )
• reduced absolute cell numbers when tested in competitive mixed bone marrow chimeras
decreased DN2 thymocyte number ( J:167000 )
• reduced absolute cell numbers when tested in competitive mixed bone marrow chimeras
decreased DN3 thymocyte number ( J:167000 )
• reduced absolute cell numbers when tested in competitive mixed bone marrow chimeras
decreased DN4 thymocyte number ( J:167000 )
• reduced absolute cell numbers when tested in competitive mixed bone marrow chimeras
increased DN1 thymic pro-T cell number ( J:167000 )
• increased relative numbers of DN1 compared to the corresponding control at 16 days after intrathymic transfer of Lin- bone marrow progenitors
decreased double-positive T cell number ( J:167000 )
• reduced numbers of DP thymocytes after competitive intrathymic transfer
decreased gamma-delta T cell number ( J:167000 )
• reduced frequency and absolute numbers of gamma-delta T cells when tested in competitive mixed bone marrow chimeras

endocrine/exocrine glands
thymus hypoplasia ( J:167000 )
• reduced total, DP, CD4 SP and CD8 SP cell numbers in the thymus when tested in competitive mixed bone marrow chimeras
• dramatic failure of bone marrow progenitors to contribute to thymus cellularity (total and DP) in competitive mixed bone marrow chimeras
• normal thymic B cells
• normal cell death and proliferative capacity
decreased DN1 thymic pro-T cell number ( J:167000 )
• reduced absolute cell numbers when tested in competitive mixed bone marrow chimeras
decreased DN2 thymocyte number ( J:167000 )
• reduced absolute cell numbers when tested in competitive mixed bone marrow chimeras
decreased DN3 thymocyte number ( J:167000 )
• reduced absolute cell numbers when tested in competitive mixed bone marrow chimeras
decreased DN4 thymocyte number ( J:167000 )
• reduced absolute cell numbers when tested in competitive mixed bone marrow chimeras
increased DN1 thymic pro-T cell number ( J:167000 )
• increased relative numbers of DN1 compared to the corresponding control at 16 days after intrathymic transfer of Lin- bone marrow progenitors




Genotype
MGI:4868730
cn4
Allelic
Composition		 Hes1tm1.1Frad/Hes1tm1.1Frad
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes1tm1.1Frad mutation (0 available); any Hes1 mutation (21 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:167000 )
N
• normal T cell development




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory