All Phenotypes Ptpn11<tm3Bgn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ptpn11^tm3Bgn
targeted mutation 3, Benjamin G Neel
MGI:4868451

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ptpn11^tm3Bgn/Ptpn11^tm3Bgn	involves: 129X1/SvJ * C57BL/6J	MGI:4868456
cn2	Ptpn11^tm3Bgn/Ptpn11^tm3Bgn Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA	MGI:4868455

Allelic Composition	Ptpn11^tm3Bgn/Ptpn11^tm3Bgn
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11^tm3Bgn mutation (1 available); any Ptpn11 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

improved glucose tolerance ( J:167406 )

• in mice treated with an adenovirus-cre to achieve liver-specific deletion

Allelic Composition	Ptpn11^tm3Bgn/Ptpn11^tm3Bgn Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11^tm3Bgn mutation (1 available); any Ptpn11 mutation (43 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:167406 )

• in fasted and fed mice

• following insulin injection

decreased circulating insulin level ( J:167406 )

• in fasted mice

decreased circulating triglyceride level ( J:167406 )

• in fasted mice

improved glucose tolerance ( J:167406 )

• mice exhibit increased ability to clear glucose during a glucose tolerance test compared with wild-type mice

increased insulin sensitivity ( J:167406 )

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