Phenotypes associated with this allele

• Allele Symbol: Ptpn11^tm3Bgn
• Allele Name: targeted mutation 3, Benjamin G Neel
• Allele ID: MGI:4868451
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ptpn11^tm3Bgn/Ptpn11^tm3Bgn	involves: 129X1/SvJ * C57BL/6J	MGI:4868456
cn2	Ptpn11^tm3Bgn/Ptpn11^tm3Bgn Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA	MGI:4868455

Genotype
MGI:4868456

cn1

• Allelic Composition: Ptpn11^tm3Bgn/Ptpn11^tm3Bgn
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

improved glucose tolerance ( J:167406 )

• in mice treated with an adenovirus-cre to achieve liver-specific deletion

Genotype
MGI:4868455

cn2

• Allelic Composition: Ptpn11^tm3Bgn/Ptpn11^tm3Bgn; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6J * DBA

homeostasis/metabolism

decreased circulating glucose level ( J:167406 )

• in fasted and fed mice

• following insulin injection

decreased circulating insulin level ( J:167406 )

• in fasted mice

decreased circulating triglyceride level ( J:167406 )

• in fasted mice

improved glucose tolerance ( J:167406 )

• mice exhibit increased ability to clear glucose during a glucose tolerance test compared with wild-type mice

increased insulin sensitivity ( J:167406 )