All Phenotypes Cxcr2<tm1a(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cxcr2^{tm1a(EUCOMM)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4842593

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxcr2^{tm1a(EUCOMM)Wtsi}/Cxcr2^{tm1a(EUCOMM)Wtsi}	C57BL/6N-Cxcr2^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5700857
ht2	Cxcr2^{tm1a(EUCOMM)Wtsi}/Cxcr2⁺	C57BL/6N-Cxcr2^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5705980

Allelic Composition	Cxcr2^{tm1a(EUCOMM)Wtsi}/Cxcr2^{tm1a(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Cxcr2^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0664_3_D02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr2^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Cxcr2 mutation (31 available)

Data Sources

IMPC Data for Cxcr2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased pre-pro B cell number ( J:211773 )

IMPC - WTSI

decreased mean corpuscular hemoglobin ( J:211773 )

IMPC - WTSI

increased red blood cell distribution width ( J:211773 )

IMPC - WTSI

thrombocytosis ( J:211773 )

IMPC - WTSI

increased CD103-positive CD11b-low dendritic cell number ( J:211773 )

IMPC - WTSI

decreased B cell number ( J:211773 )

IMPC - WTSI

decreased immature B cell number ( J:211773 )

IMPC - WTSI

decreased mature B cell number ( J:211773 )

IMPC - WTSI

decreased pre-B cell number ( J:211773 )

IMPC - WTSI

increased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

decreased T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased leukocyte cell number ( J:211773 )

IMPC - WTSI

increased granulocyte number ( J:211773 )

IMPC - WTSI

increased eosinophil cell number ( J:211773 )

IMPC - WTSI

increased neutrophil cell number ( J:211773 )

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD4 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD8 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

increased gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

increased Ly6C high monocyte number ( J:211773 )

IMPC - WTSI

increased Ly6C low monocyte number ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

decreased circulating fructosamine level ( J:211773 )

IMPC - WTSI

decreased circulating thyroxine level ( J:211773 )

IMPC - WTSI

increased circulating calcium level ( J:211773 )

IMPC - WTSI

decreased circulating serum albumin level ( J:211773 )

IMPC - WTSI

increased circulating total protein level ( J:211773 )

IMPC - WTSI

improved glucose tolerance ( J:211773 )

IMPC - WTSI

immune system

decreased pre-pro B cell number ( J:211773 )

IMPC - WTSI

increased CD103-positive CD11b-low dendritic cell number ( J:211773 )

IMPC - WTSI

decreased B cell number ( J:211773 )

IMPC - WTSI

decreased immature B cell number ( J:211773 )

IMPC - WTSI

decreased mature B cell number ( J:211773 )

IMPC - WTSI

decreased pre-B cell number ( J:211773 )

IMPC - WTSI

increased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

decreased T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased leukocyte cell number ( J:211773 )

IMPC - WTSI

increased granulocyte number ( J:211773 )

IMPC - WTSI

increased eosinophil cell number ( J:211773 )

IMPC - WTSI

increased neutrophil cell number ( J:211773 )

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD4 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD8 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

increased gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

increased Ly6C high monocyte number ( J:211773 )

IMPC - WTSI

increased Ly6C low monocyte number ( J:211773 )

IMPC - WTSI

increased anti-nuclear antigen antibody level ( J:211773 )

IMPC - WTSI

Allelic Composition	Cxcr2^{tm1a(EUCOMM)Wtsi}/Cxcr2⁺
Genetic Background	C57BL/6N-Cxcr2^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0664_3_D02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr2^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Cxcr2 mutation (31 available)

Data Sources

IMPC Data for Cxcr2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating creatinine level ( J:211773 )

IMPC - WTSI

increased circulating magnesium level ( J:211773 )

IMPC - WTSI

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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