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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atp4am1Btlr
mutation 1, Bruce Beutler
MGI:4839212
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atp4am1Btlr/Atp4am1Btlr involves: C57BL/6J MGI:5302235
ht2
 		Atp4am1Btlr/Atp4atm1Ges involves: 129X1/SvJ * Black Swiss * C57BL/6J MGI:5302234


Genotype
MGI:5302235
hm1
Allelic
Composition		 Atp4am1Btlr/Atp4am1Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp4am1Btlr mutation (1 available); any Atp4a mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
gastric cyst ( J:179090 )
• glandular and parietal, increasing in size and number with age
enlarged spleen ( J:179090 )

mortality/aging
mortality/aging ( J:179090 )
N
• mice have a normal lifespan

hematopoietic system
hematopoietic system phenotype ( J:179090 )
N
• mice exhibit normal leukocyte numbers and morphology
hypochromic anemia ( J:179090 )
• severe anemia occurs between 10 and 20 months of age
• however, anemia in mice fed a high-iron diet or a HCL-acidified drinking water is rescued
increased erythroid progenitor cell number ( J:179090 )
• in the bone marrow and spleen
abnormal erythrocyte morphology ( J:179090 )
• however, red blood cell indices are normalized by HCL-acidified drinking water
abnormal erythropoiesis ( J:179090 )
• compensatory erythropoiesis
decreased hematocrit ( J:179090 )
• not rescued by transplantation of wild-type bone marrow
decreased hemoglobin content ( J:179090 )
• until 8 weeks of age
• not rescued by transplantation of wild-type bone marrow
decreased mean corpuscular volume ( J:179090 )
• not rescued by transplantation of wild-type bone marrow
thrombocytosis ( J:179090 )
• in some mice
reticulocytosis ( J:179090 )
• until 8 weeks of age
abnormal spleen morphology ( J:179090 )
• due to extramedullary hematopoiesis
decreased erythrocyte osmotic fragility ( J:179090 )
• resistant to osmotic lysis

digestive/alimentary system
abnormal stomach morphology ( J:179090 )
• indurated and enlarged
gastric cyst ( J:179090 )
• glandular and parietal, increasing in size and number with age

homeostasis/metabolism
abnormal iron homeostasis ( J:179090 )
• when fed an iron-deficient diet, mice exhibit reduced iron absorption compared with wild-type mice
• however, mice fed a regular diet exhibit normal iron absorption
decreased circulating iron level ( J:179090 )
• however, serum iron levels are rescued by HCL-acidified drinking water

immune system
abnormal spleen morphology ( J:179090 )
• due to extramedullary hematopoiesis




Genotype
MGI:5302234
ht2
Allelic
Composition		 Atp4am1Btlr/Atp4atm1Ges
Genetic
Background		 involves: 129X1/SvJ * Black Swiss * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp4am1Btlr mutation (1 available); any Atp4a mutation (63 available)
Atp4atm1Ges mutation (2 available); any Atp4a mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hypochromic microcytic anemia ( J:179090 )
• at 4 weeks of age

homeostasis/metabolism




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory