Phenotypes associated with this allele

• Allele Symbol: Pip5k1c^tm1.2Ref
• Allele Name: targeted mutation 1.2, Reinhard Fassler
• Allele ID: MGI:4838023
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pip5k1c^tm1.2Ref/Pip5k1c^tm1.2Ref	involves: 129	MGI:5509218
cx2	Pip5k1c^tm1.2Ref/Pip5k1c^tm1.2Ref Tg(TcraTcrb)425Cbn/0	involves: BALB/c * C57BL/6	MGI:4838029

Genotype
MGI:5509218

hm1

• Allelic Composition: Pip5k1c^tm1.2Ref/Pip5k1c^tm1.2Ref
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:200273 )

N • mice are born in Mendelian ratios

nervous system

abnormal synaptic vesicle recycling ( J:200273 )

• defective synaptic vesicle endocytosis

behavior/neurological

decreased startle reflex ( J:200273 )

• reduced magnitude of response, also at several prepulse intensities

• however, mice exhibit normal prepulse inhibition

cellular

abnormal cell physiology ( J:200273 )

• agonist-induced calcium signaling is enhanced in fibroblasts compared with wild-type cells

Genotype
MGI:4838029

cx2

• Allelic Composition: Pip5k1c^tm1.2Ref/Pip5k1c^tm1.2Ref; Tg(TcraTcrb)425Cbn/0
• Genetic Background: involves: BALB/c * C57BL/6

immune system

decreased dendritic cell number ( J:164732 )

decreased B cell number ( J:164732 )

abnormal T cell physiology ( J:164732 )

• adhesion to ICAM-1 is increased compared to in wild-type cells

• T cell-APC conjugate formation is decreased compared to in wild-type cells

increased T cell proliferation ( J:164732 )

• CD4+ T cells exhibit increased proliferation in vitro and in vivo compared with similarly treated wild-type cells

increased interferon-gamma secretion ( J:164732 )

• following activation with ovalbumin peptide and restimulation with anti-CD3 and anti-CD28 antibodies

increased interleukin-2 secretion ( J:164732 )

• following activation with ovalbumin peptide and restimulation with anti-CD3 and anti-CD28 antibodies

hematopoietic system

decreased dendritic cell number ( J:164732 )

decreased B cell number ( J:164732 )

abnormal T cell physiology ( J:164732 )

• adhesion to ICAM-1 is increased compared to in wild-type cells

• T cell-APC conjugate formation is decreased compared to in wild-type cells

increased T cell proliferation ( J:164732 )

• CD4+ T cells exhibit increased proliferation in vitro and in vivo compared with similarly treated wild-type cells

cellular

increased T cell proliferation ( J:164732 )

• CD4+ T cells exhibit increased proliferation in vitro and in vivo compared with similarly treated wild-type cells