Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Senp1tm1Wami mutation
(0 available);
any
Senp1 mutation
(65 available)
Tg(Pdgfra-cre)1Clc mutation
(1 available)
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homeostasis/metabolism
growth/size/body
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• lower body weight after onset of diabetes
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endocrine/exocrine glands
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• increase in apoptosis of beta cells
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• structures of pancreatic islets are disrupted, with increased apoptosis of beta cells after onset of diabetes and more severe at later stages
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• increase in apoptosis of beta cells after onset of diabetes and more severe at later stages
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cellular
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• increase in apoptosis of beta cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crb2tm1.1Wij mutation
(0 available);
any
Crb2 mutation
(52 available)
Tg(Pdgfra-cre)1Clc mutation
(1 available)
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mortality/aging
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• mice are born at a 5-fold reduced ratio than expected
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vision/eye
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• protrusion of photoreceptor nuclei into the subretinal space at sites of outer limiting membrane disruption at 5 months of age
• however, 5 month old mice show normal electroretinography (ERG), scanning laser ophthalmoscopy, and spectral domain optical coherence tomography readings
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• ectopic Muller glial cell nuclei in the outer nuclear layer and activated Muller glial cells are seen at 5 months of age
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• at 5 months of age, a reduction of the outer nuclear layer thickness is seen
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• disruptions of the outer limiting membrane at the periphery of the retina, where rows of photoreceptor nuclei protrude into the subretinal space, are seen at 1, 3, and 5 months of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igs1tm11(CAG-Bgeo,-Edn2)Nat mutation
(1 available);
any
Igs1 mutation
(10 available)
Tg(Pdgfra-cre)1Clc mutation
(1 available)
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Interstitial tip cells in adult Igs1tm11(CAG-Bgeo,-Edn2)Nat/Igs1+ Tg(Pdgfra-cre)1Clc/0 retinas
vision/eye
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• intraretinal capillaries are larger and more numerous; however a large number of these terminate with blind endings
• blind endings are most numerous in the inner plexiform layer and are typically decorated with multiple filopodia
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cardiovascular system
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• intraretinal capillaries are larger and more numerous; however a large number of these terminate with blind endings
• blind endings are most numerous in the inner plexiform layer and are typically decorated with multiple filopodia
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bbs1tm2Vcs mutation
(0 available);
any
Bbs1 mutation
(70 available)
Tg(Pdgfra-cre)1Clc mutation
(1 available)
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nervous system
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• motile cilia in the lateral ventricles are normal
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• non-obstructive beginning at P3
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cellular
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Glh mutation
(0 available);
any
Acvr1 mutation
(44 available)
Gt(ROSA)26Sortm1.2(CAG-EGFP)Glh mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Tg(Pdgfra-cre)1Clc mutation
(1 available)
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homeostasis/metabolism
skeleton
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• spontaneous heterotopic ossification is seen infrequently in some 2-week-old mice and is present in all 4-week-old mice and extensive in all surviving mice by 6 weeks of age
• heterotopic ossification is seen in the musculature, tendons, and ligaments at diverse locations
• skeletal elements resulting from spontaneous heterotopic ossification are derived almost exclusively from recombined cells
• all mice treated with an anti-activin A mAb prior to onset of heterotopic ossification for 4 weeks survive to 6 weeks of age and 8 of 9 mice show no evidence of heterotopic ossification and no spontaneous heterotopic ossification is not seen in treated 16-week-old mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephx2tm1.1Arte mutation
(0 available);
any
Ephx2 mutation
(39 available)
Tg(Pdgfra-cre)1Clc mutation
(1 available)
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cardiovascular system
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• significant delay in the radial extension of the vascular plexus from the optic nerve to the periphery and decrease in the number of tip cells and filopodia
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• significant delay in the radial extension of the vascular plexus from the optic nerve to the periphery and decrease in the number of tip cells and filopodia
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vision/eye
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• significant delay in the radial extension of the vascular plexus from the optic nerve to the periphery and decrease in the number of tip cells and filopodia
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Analysis Tools