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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ncoa6tm3Jxu
targeted mutation 3, Jianming Xu
MGI:4837687
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ncoa6tm3Jxu/Ncoa6tm3Jxu
Pgrtm2(cre)Lyd/Pgr+ 		involves: 129/Sv * C57BL/6 * SJL MGI:5444650
cn2
 		Ncoa6tm3Jxu/Ncoa6tm3.1Jxu
Tg(Pax6-cre,GFP)1Pgr/0 		involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:4837886
cn3
 		Ncoa6tm3Jxu/Ncoa6tm3Jxu
Tg(Pax6-cre,GFP)1Pgr/0 		involves: 129S6/SvEvTac * FVB/N MGI:4837887


Genotype
MGI:5444650
cn1
Allelic
Composition		 Ncoa6tm3Jxu/Ncoa6tm3Jxu
Pgrtm2(cre)Lyd/Pgr+
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa6tm3Jxu mutation (0 available); any Ncoa6 mutation (100 available)
Pgrtm2(cre)Lyd mutation (0 available); any Pgr mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal decidualization ( J:189065 )
• the decidual response is diminished
abnormal luminal closure ( J:189065 )
• display intricately extended luminal and glandular epithelia that surround the curving lumens with many branches on the uterine cross-sections suggesting epithelial overgrowth
abnormal uterine receptivity ( J:189065 )
• no implantation sites are found
• embryos transferred into control females are able to attach to the uterus
• treatment with a low dose of an estrogen receptor antagonist rescues embryo implantation
female infertility ( J:189065 )
• ovulation and blastocyst formation are normal but no implantation sites are found

embryo
abnormal decidualization ( J:189065 )
• the decidual response is diminished




Genotype
MGI:4837886
cn2
Allelic
Composition		 Ncoa6tm3Jxu/Ncoa6tm3.1Jxu
Tg(Pax6-cre,GFP)1Pgr/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa6tm3.1Jxu mutation (0 available); any Ncoa6 mutation (100 available)
Ncoa6tm3Jxu mutation (0 available); any Ncoa6 mutation (100 available)
Tg(Pax6-cre,GFP)1Pgr mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
cataract ( J:165054 )
• at P21 to 2.5 months
small lens ( J:165054 )
• lens phenotype are less severe than in Tg(Cryaa-NCOA6*)AD5Cve mice




Genotype
MGI:4837887
cn3
Allelic
Composition		 Ncoa6tm3Jxu/Ncoa6tm3Jxu
Tg(Pax6-cre,GFP)1Pgr/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa6tm3Jxu mutation (0 available); any Ncoa6 mutation (100 available)
Tg(Pax6-cre,GFP)1Pgr mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
cataract ( J:165054 )
• at P21 to 2.5 months
small lens ( J:165054 )
• lens phenotype are less severe than in Tg(Cryaa-NCOA6*)AD5Cve mice




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory