Phenotypes associated with this allele

• Allele Symbol: +
• Allele Name: wild type
• Allele ID: MGI:4835780
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cmtm5^tm1d(KOMP)Wtsi/Cmtm5^tm1d(KOMP)Wtsi Wld^s/+	B6(Cg)-Wld^s Cmtm5^tm1d(KOMP)Wtsi	MGI:7331615
cx2	Nmnat2^Gt(EUCE0262a08)Hmgu/Nmnat2^Gt(EUCE0262a08)Hmgu Wld^s/+	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6Ola	MGI:5543591
cx3	Tg(SOD1*G93A)1Gur/0 Wld^s/+	involves: C57BL/6J * C57BL/6Ola * SJL/J	MGI:4835781

Genotype
MGI:7331615

cx1

• Allelic Composition: Cmtm5^{tm1d(KOMP)Wtsi}/Cmtm5^{tm1d(KOMP)Wtsi}; Wld^s/+
• Genetic Background: B6(Cg)-Wld^s Cmtm5^{tm1d(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon morphology ( J:327261 )

• mice show reduced number of pathologically appearing axons in optic nerves at 6 months of age compared to homozygous Cmtm5^{tm1d(KOMP)Wtsi} mice but still increased number compared to wild-type mice

Genotype
MGI:5543591

cx2

• Allelic Composition: Nmnat2^{Gt(EUCE0262a08)Hmgu}/Nmnat2^{Gt(EUCE0262a08)Hmgu}; Wld^s/+
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6Ola

mortality/aging

neonatal lethality, complete penetrance ( J:200901 )

• die within a few hours of birth

• unlike Nmnat2 single mutants, double mutants initiate breathing in most cases

behavior/neurological

behavior/neurological phenotype ( J:200901 )

N • unlike Nmnat2 single mutants, double mutants do not display a hunched posture

muscle

muscle phenotype ( J:200901 )

N • unlike Nmnat2 single mutants, muscle mass and diaphragm morphology are similar to controls in double mutants

nervous system

nervous system phenotype ( J:200901 )

N • at E14.5 intercostal and hindlimb nerves show a grossly normal morphology and loss of dorsal root ganglia cells and spinal cord motor neurons later in development is largely prevented, unlike in Nmnat2 single mutants

N • the optic nerve and olfactory bulb defects in single Nmnat2 single mutants are largely rescued in double mutants

renal/urinary system

renal/urinary system phenotype ( J:200901 )

N • unlike Nmnat2 single mutants, double mutants do not display a distended bladder

Genotype
MGI:4835781

cx3

• Allelic Composition: Tg(SOD1*G93A)1Gur/0; Wld^s/+
• Genetic Background: involves: C57BL/6J * C57BL/6Ola * SJL/J

mortality/aging

premature death ( J:105092 )

• prolonged survival (141.98.9 vs. 131.13.7 days), compare with Tg(SOD1*G93A)1Gur mice

• female mice survive longer than the male (145.48.2 vs. 137.67.9 days)

nervous system

slow Wallerian degeneration ( J:105092 )

• 5 days after sciatic nerve transection, mice show delayed Wallerian degeneration, while Tg(SOD1*G93A)1Gur mice show a loss of axons and presence of myelin ovoids and phagocytes

abnormal motor neuron innervation pattern ( J:105092 )

• delayed denervation at the neuromuscular junction

• more axons and innervated neuromuscular junctions in nerve roots than Tg(SOD1*G93A)1Gur mutants at day 80

decreased motor neuron number ( J:105092 )

• similar levels of ventral root axon loss to that seen in Tg(SOD1*G93A)1Gur mice

decreased sensory neuron number ( J:105092 )

• similar levels of dorsal root axon loss to that seen in Tg(SOD1*G93A)1Gur mice

homeostasis/metabolism

slow Wallerian degeneration ( J:105092 )

• 5 days after sciatic nerve transection, mice show delayed Wallerian degeneration, while Tg(SOD1*G93A)1Gur mice show a loss of axons and presence of myelin ovoids and phagocytes