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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Actbtm1(INSR)Dac
targeted mutation 1, Dominico Accili
MGI:4831148
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Hsp70-1-cre)6Arge/? 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:4831153
cn2
 		Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Syn1-cre)671Jxm/? 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA MGI:4831155
cn3
 		Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Nes-cre)1Kln/? 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL MGI:4831154
cn4
 		Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Camk2a-cre)#Szi/? 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA MGI:4831152
cx5
 		Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:4831156


Genotype
MGI:4831153
cn1
Allelic
Composition		 Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Hsp70-1-cre)6Arge/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (55 available)
Insrtm1Dac mutation (2 available); any Insr mutation (95 available)
Tg(Hsp70-1-cre)6Arge mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:91350 )
• die between 6 and 8 weeks

homeostasis/metabolism
increased circulating glucose level ( J:91350 )
• diabetic in one week
increased circulating insulin level ( J:91350 )
• extremely elevated




Genotype
MGI:4831155
cn2
Allelic
Composition		 Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Syn1-cre)671Jxm/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (55 available)
Insrtm1Dac mutation (2 available); any Insr mutation (95 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:91350 )
• die between 6 and 8 weeks

homeostasis/metabolism
increased circulating glucose level ( J:91350 )
• diabetic in one week
increased circulating insulin level ( J:91350 )
• extremely elevated




Genotype
MGI:4831154
cn3
Allelic
Composition		 Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Nes-cre)1Kln/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (55 available)
Insrtm1Dac mutation (2 available); any Insr mutation (95 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:91350 )
• die between 6 and 8 weeks

homeostasis/metabolism
increased circulating glucose level ( J:91350 )
• diabetic in one week
increased circulating insulin level ( J:91350 )
• extremely elevated




Genotype
MGI:4831152
cn4
Allelic
Composition		 Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Camk2a-cre)#Szi/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (55 available)
Insrtm1Dac mutation (2 available); any Insr mutation (95 available)
Tg(Camk2a-cre)#Szi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:91350 )
• die between 6 and 8 weeks

homeostasis/metabolism
increased circulating glucose level ( J:91350 )
• diabetic in one week
increased circulating insulin level ( J:91350 )
• extremely elevated




Genotype
MGI:4831156
cx5
Allelic
Composition		 Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (55 available)
Insrtm1Dac mutation (2 available); any Insr mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:91350 )
• die within a few days of birth

homeostasis/metabolism
increased circulating ketone body level ( J:91350 )
• diabetic ketosis
• cause of early death




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory