Phenotypes associated with this allele

• Allele Symbol: Rela^tm2.1Gho
• Allele Name: targeted mutation 2.1, Sankar Ghosh
• Allele ID: MGI:4830882
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rela^tm2.1Gho/Rela^tm2.1Gho	involves: 129S6/SvEvTac * C57BL/6	MGI:4830883
cx2	Rela^tm2.1Gho/Rela^tm2.1Gho Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129S2/SvPas * 129S6/SvEvTac	MGI:5574110

Genotype
MGI:4830883

hm1

• Allelic Composition: Rela^tm2.1Gho/Rela^tm2.1Gho
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:163663 )

• typically die 8-20 d after birth

growth/size/body

decreased body size ( J:163663 )

• dramatically runted animals by P8-P10

postnatal growth retardation ( J:163663 )

• mice exhibit progressive growth retardation, beginning at postnatal day P4-P5

immune system

increased neutrophil cell number ( J:163663 )

• immature and mature neutrophils on peripheral blood smear

abnormal spleen morphology ( J:163663 )

• authors state spleen exhibits features similar to the liver

increased inflammatory response ( J:163663 )

• systemic inflammation

liver inflammation ( J:163663 )

• histiocytic inflammatory infiltrates

myositis ( J:163663 )

lung inflammation ( J:163663 )

interstitial pneumonia ( J:163663 )

• multifocal suppurative and histiocytic interstitial and perivascular pneumonia

muscle

myositis ( J:163663 )

respiratory system

lung inflammation ( J:163663 )

interstitial pneumonia ( J:163663 )

• multifocal suppurative and histiocytic interstitial and perivascular pneumonia

hematopoietic system

extramedullary hematopoiesis ( J:163663 )

• extramedullary hematopoeisis with a predominance of myeloid and megakaryocytic cells

increased neutrophil cell number ( J:163663 )

• immature and mature neutrophils on peripheral blood smear

abnormal spleen morphology ( J:163663 )

• authors state spleen exhibits features similar to the liver

liver/biliary system

hepatic necrosis ( J:163663 )

• accompanied by dying hepatocytes

liver inflammation ( J:163663 )

• histiocytic inflammatory infiltrates

liver hypoplasia ( J:163663 )

• in rare aged mouse (3.5 months) liver is shrunken and distorted

liver fibrosis ( J:163663 )

• in rare aged mouse (3.5 months) liver is distorted by bridging fibrosis extending from the capsule through the parenchyma, multifocal capsular fibrosis and lymphocytic inflammation that extended into underlying parenchyma are also seen

nervous system

abnormal brain morphology ( J:163663 )

• authors state brain exhibits features similar to the liver

cardiovascular system

abnormal heart morphology ( J:163663 )

• authors state heart exhibits features similar to the liver

digestive/alimentary system

abnormal colon morphology ( J:163663 )

• authors state colon exhibits features similar to the liver

skeleton

abnormal bone structure ( J:163663 )

• authors state bone exhibits features similar to the liver

integument

epidermal necrosis ( J:163663 )

distorted hair follicle pattern ( J:163663 )

• shortened distorted hair follicles

small hair follicles ( J:163663 )

• shortend

epidermal hyperplasia ( J:163663 )

skin fibrosis ( J:163663 )

• suppurative dermatitis with dermal fibrosis and multifocal epidermal necrosis

cellular

epidermal necrosis ( J:163663 )

hepatic necrosis ( J:163663 )

• accompanied by dying hepatocytes

Genotype
MGI:5574110

cx2

• Allelic Composition: Rela^tm2.1Gho/Rela^tm2.1Gho; Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

mortality/aging

premature death ( J:163663 )

• 50%-60% die sometime between 1 and 6 months of age

vision/eye

cornea vascularization ( J:163663 )

• vascularized and proliferative corneal lesion developed in the central region of the cornea

increased incidence of corneal inflammation ( J:163663 )

• neutrophils and macrophages

abnormal cornea epithelium morphology ( J:163663 )

• occasional dying keratinocytes are present

increased cornea epithelium thickness ( J:163663 )

• severe corneal epithelial thickening is observed, occurring abruptly at the junction of the central and peripheral

decreased cornea thickness ( J:163663 )

• at 25 days, the corneal epithelium is slightly thinner and keratinocytes are less orderly

liver/biliary system

liver inflammation ( J:163663 )

• slowly progressive hepatic inflammation

• Inflammatory foci are characterized by an increasing number of interstitial and perivascular macrophages with fewer neutrophils

liver fibrosis ( J:163663 )

• capsular fibrosis and inflammation is also seen

cardiovascular system

cornea vascularization ( J:163663 )

• vascularized and proliferative corneal lesion developed in the central region of the cornea

immune system

increased incidence of corneal inflammation ( J:163663 )

• neutrophils and macrophages

liver inflammation ( J:163663 )

• slowly progressive hepatic inflammation

• Inflammatory foci are characterized by an increasing number of interstitial and perivascular macrophages with fewer neutrophils