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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfaip3tm1.1Gvl
targeted mutation 1.1, Geert van Loo
MGI:4829650
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl
Tg(Vil1-cre)997Gum/0 		B6.Cg-Tnfaip3tm1.1Gvl Tg(Vil1-cre)997Gum MGI:4829679
cn2
 		Myd88tm1Aki/Myd88tm1Aki
Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl
Tg(Vil1-cre)997Gum/0 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:4829678
cn3
 		Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Vil1-cre)997Gum/0 		involves: 129S2/SvPas * C57BL/6 * SJL MGI:4829677


Genotype
MGI:4829679
cn1
Allelic
Composition		 Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl
Tg(Vil1-cre)997Gum/0
Genetic
Background		 B6.Cg-Tnfaip3tm1.1Gvl Tg(Vil1-cre)997Gum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tnfaip3tm1.1Gvl mutation (0 available); any Tnfaip3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:163410 )
• TNF-treated mice exhibit increased mortality compared with similarly treated wild-type mice
• however, mice treated with broad-spectrum antibiotics are protected against TNF toxicity-induced lethality
increased susceptibility to xenobiotic induced morbidity/mortality ( J:163410 )
• in DDS-treated mice during the recovery phase

homeostasis/metabolism
impaired adaptive thermogenesis ( J:163410 )
• TNF-treated mice exhibit hypothermia unlike similarly treated wild-type mice
abnormal response/metabolism to endogenous compounds ( J:163410 )
• TNF-treated mice exhibit TNF toxicity (including hypothermia, severe diarrhea, and increased mortality) at doses that are sub-lethal in wild-type mice
• however, mice treated with broad-spectrum antibiotics are protected against TNF toxicity-induced mortality, hypothermia, and liver damage
increased susceptibility to xenobiotic induced morbidity/mortality ( J:163410 )
• in DDS-treated mice during the recovery phase

digestive/alimentary system
rectal hemorrhage ( J:163410 )
• in DDS-treated mice
increased enterocyte apoptosis ( J:163410 )
• in DDS-treated mice and more profound in the recovery phase
• in TNF-treated mice
abnormal small intestine crypts of Lieberkuhn morphology ( J:163410 )
• TNF-treated mice exhibit increased intestinal damage with near complete loss of crypt-villus structure unlike in similarly treated wild-type mice
• antibiotic treatment does not rescue TNF-induced intestinal damage
decreased colon length ( J:163410 )
• DDS-treated mice exhibit increased colonic shortening compared with wild-type mice
diarrhea ( J:163410 )
• in DDS-treated mice
• in TNF-treated mice
increased susceptibility to induced colitis ( J:163410 )
• DDS-treated mice exhibit more severe colitis symptoms such as rectal bleeding, diarrhea, colon shortening, colonic inflammation, mucosal damage, crypt loss, immune cell infiltration, increased IL6 serum levels, loss of body weight, increased intestinal epithelial cell apoptosis, and mortality compared with wild-type mice

growth/size/body
increased susceptibility to weight loss ( J:163410 )
• in DDS-treated mice

cardiovascular system
rectal hemorrhage ( J:163410 )
• in DDS-treated mice

liver/biliary system
liver degeneration ( J:163410 )
• in TNF-treated mice

immune system
increased susceptibility to induced colitis ( J:163410 )
• DDS-treated mice exhibit more severe colitis symptoms such as rectal bleeding, diarrhea, colon shortening, colonic inflammation, mucosal damage, crypt loss, immune cell infiltration, increased IL6 serum levels, loss of body weight, increased intestinal epithelial cell apoptosis, and mortality compared with wild-type mice

endocrine/exocrine glands
abnormal small intestine crypts of Lieberkuhn morphology ( J:163410 )
• TNF-treated mice exhibit increased intestinal damage with near complete loss of crypt-villus structure unlike in similarly treated wild-type mice
• antibiotic treatment does not rescue TNF-induced intestinal damage

cellular
increased enterocyte apoptosis ( J:163410 )
• in DDS-treated mice and more profound in the recovery phase
• in TNF-treated mice




Genotype
MGI:4829678
cn2
Allelic
Composition		 Myd88tm1Aki/Myd88tm1Aki
Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88tm1Aki mutation (9 available); any Myd88 mutation (50 available)
Tg(Vil1-cre)997Gum mutation (2 available)
Tnfaip3tm1.1Gvl mutation (0 available); any Tnfaip3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased enterocyte apoptosis ( J:163410 )
• in DDS-treated mice
increased susceptibility to induced colitis ( J:163410 )
• mice exhibit increased susceptibility compared to in Myd88tm1Aki/Myd88+ Tnfaip3tm1.1Gvl Tg(Vil-cre)997Gum mice or Myd88tm1Aki homozygotes

immune system
increased susceptibility to induced colitis ( J:163410 )
• mice exhibit increased susceptibility compared to in Myd88tm1Aki/Myd88+ Tnfaip3tm1.1Gvl Tg(Vil-cre)997Gum mice or Myd88tm1Aki homozygotes

cellular
increased enterocyte apoptosis ( J:163410 )
• in DDS-treated mice




Genotype
MGI:4829677
cn3
Allelic
Composition		 Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl
Tnfrsf1atm1Mak/Tnfrsf1atm1Mak
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tnfaip3tm1.1Gvl mutation (0 available); any Tnfaip3 mutation (43 available)
Tnfrsf1atm1Mak mutation (2 available); any Tnfrsf1a mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased susceptibility to induced colitis ( J:163410 )
• mice exhibit decreased susceptibility compared to Tnfrsf1atm1Mak/Tnfrf1+ Tnfaip3tm1.1Gvl Tg(Vil-cre)997Gum mice
increased susceptibility to induced colitis ( J:163410 )
• mice exhibit increased susceptibility compared to in Tnfrsf1atm1Mak homozygotes

immune system
decreased susceptibility to induced colitis ( J:163410 )
• mice exhibit decreased susceptibility compared to Tnfrsf1atm1Mak/Tnfrf1+ Tnfaip3tm1.1Gvl Tg(Vil-cre)997Gum mice
increased susceptibility to induced colitis ( J:163410 )
• mice exhibit increased susceptibility compared to in Tnfrsf1atm1Mak homozygotes




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory