Phenotypes associated with this allele

• Allele Symbol: Cog6^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4820323
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cog6^tm1a(EUCOMM)Wtsi/Cog6^tm1a(EUCOMM)Wtsi	C57BL/6N-Cog6^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5767608

Genotype
MGI:5767608

hm1

• Allelic Composition: Cog6^{tm1a(EUCOMM)Wtsi}/Cog6^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Cog6^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0609_4_H05

Data Sources

IMPC Data for Cog6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vertebral artery topology ( J:239583 )

DMDD

abnormal liver vasculature morphology ( J:239583 )

DMDD

abnormal vitelline vein connection ( J:239583 )

DMDD

abnormal ductus venosus valve morphology ( J:239583 )

DMDD

abnormal inferior vena cava morphology ( J:239583 )

DMDD

dual inferior vena cava ( J:239583 )

DMDD

abnormal coronary sinus connection ( J:239583 )

DMDD

abnormal inferior vena cava valve morphology ( J:239583 )

DMDD

muscular ventricular septal defect ( J:239583 )

DMDD

intracerebral hemorrhage ( J:239583 )

DMDD

embryo

abnormal vitelline vein connection ( J:239583 )

DMDD

hematopoietic system

decreased transitional stage T2 B cell number ( J:211773 )

IMPC - WTSI

decreased erythrocyte cell number ( J:211773 )

♂

IMPC - WTSI

decreased hematocrit ( J:211773 )

♂

IMPC - WTSI

decreased hemoglobin content ( J:211773 )

♂

IMPC - WTSI

decreased mean corpuscular hemoglobin ( J:211773 )

♀

IMPC - WTSI

decreased mean corpuscular hemoglobin concentration ( J:211773 )

♀

IMPC - WTSI

increased red blood cell distribution width ( J:211773 )

♀

IMPC - WTSI

increased mean platelet volume ( J:211773 )

♀

IMPC - WTSI

decreased marginal zone B cell number ( J:211773 )

IMPC - WTSI

decreased NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive immature NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive T-helper cell number ( J:211773 )

IMPC - WTSI

increased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

decreased T cell number ( J:211773 )

IMPC - WTSI

decreased NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased T-helper cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased leukocyte cell number ( J:211773 )

♀

IMPC - WTSI

increased granulocyte number ( J:211773 )

IMPC - WTSI

increased eosinophil cell number ( J:211773 )

IMPC - WTSI

increased B-2 B cell number ( J:211773 )

IMPC - WTSI

increased follicular B cell number ( J:211773 )

IMPC - WTSI

increased plasma cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD4 alpha-beta T cell number ( J:211773 )

♂

IMPC - WTSI

increased KLRG1+ CD8 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

increased gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased CD5-positive gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

increased Ly6C high monocyte number ( J:211773 )

♀

IMPC - WTSI

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

♀

IMPC - WTSI

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - WTSI

increased circulating amylase level ( J:211773 )

IMPC - WTSI

increased circulating aspartate transaminase level ( J:211773 )

IMPC - WTSI

increased circulating total protein level ( J:211773 )

IMPC - WTSI

immune system

decreased transitional stage T2 B cell number ( J:211773 )

IMPC - WTSI

decreased marginal zone B cell number ( J:211773 )

IMPC - WTSI

decreased NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive immature NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive T-helper cell number ( J:211773 )

IMPC - WTSI

increased effector memory T-helper cell number ( J:211773 )

IMPC - WTSI

decreased T cell number ( J:211773 )

IMPC - WTSI

decreased NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased T-helper cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased leukocyte cell number ( J:211773 )

♀

IMPC - WTSI

increased granulocyte number ( J:211773 )

IMPC - WTSI

increased eosinophil cell number ( J:211773 )

IMPC - WTSI

increased B-2 B cell number ( J:211773 )

IMPC - WTSI

increased follicular B cell number ( J:211773 )

IMPC - WTSI

increased plasma cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1+ CD4 alpha-beta T cell number ( J:211773 )

♂

IMPC - WTSI

increased KLRG1+ CD8 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

increased gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased CD5-positive gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

increased Ly6C high monocyte number ( J:211773 )

♀

IMPC - WTSI

increased anti-nuclear antigen antibody level ( J:211773 )

IMPC - WTSI

integument

abnormal coat/hair pigmentation ( J:211773 )

♀

IMPC - WTSI

liver/biliary system

abnormal liver vasculature morphology ( J:239583 )

DMDD

nervous system

intracerebral hemorrhage ( J:239583 )

DMDD

thin hypoglossal nerve ( J:239583 )

DMDD

normal phenotype

no abnormal phenotype detected ( J:239583 )

DMDD

pigmentation

abnormal coat/hair pigmentation ( J:211773 )

♀

IMPC - WTSI

skeleton

fusion of vertebral arches ( J:239583 )

DMDD

vertebral transformation ( J:211773 )

♂

IMPC - WTSI

abnormal bone structure ( J:211773 )

IMPC - WTSI

decreased bone mineral content ( J:211773 )

IMPC - WTSI

vision/eye

abnormal cornea morphology ( J:211773 )

♀

IMPC - WTSI