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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vangl2tm1.2Yy
targeted mutation 1.2, Yingzi Yang
MGI:4819590
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Vangl2tm1.2Yy/Vangl2tm1.2Yy involves: C57BL/6 * CBA MGI:4819598
cx2
 		Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg
Vangl2tm1.2Yy/Vangl2+ 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4819600
cx3
 		Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg
Vangl2tm1.2Yy/Vangl2tm1.2Yy 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4819601


Genotype
MGI:4819598
hm1
Allelic
Composition		 Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl2tm1.2Yy mutation (0 available); any Vangl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cochlear inner hair cell morphology ( J:162640 )
• inner hair cells are misoriented compared to in wild-type mice
abnormal cochlear outer hair cell morphology ( J:162640 )
• outer hair cells are misoriented compared to in wild-type mice

embryo

hearing/vestibular/ear
abnormal cochlear inner hair cell morphology ( J:162640 )
• inner hair cells are misoriented compared to in wild-type mice
abnormal cochlear outer hair cell morphology ( J:162640 )
• outer hair cells are misoriented compared to in wild-type mice




Genotype
MGI:4819600
cx2
Allelic
Composition		 Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg
Vangl2tm1.2Yy/Vangl2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl1Gt(XL802)Byg mutation (1 available); any Vangl1 mutation (86 available)
Vangl2tm1.2Yy mutation (0 available); any Vangl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cochlear outer hair cell morphology ( J:162640 )
• outer hair cells in rows 3 and 2 are misoriented compared to in wild-type mice

limbs/digits/tail
long tail ( J:162640 )
• compared with Vangl2Lp/Vangl2Lp Vangl2tm1.2Yy/Vangl2+

hearing/vestibular/ear
abnormal cochlear outer hair cell morphology ( J:162640 )
• outer hair cells in rows 3 and 2 are misoriented compared to in wild-type mice




Genotype
MGI:4819601
cx3
Allelic
Composition		 Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg
Vangl2tm1.2Yy/Vangl2tm1.2Yy
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl1Gt(XL802)Byg mutation (1 available); any Vangl1 mutation (86 available)
Vangl2tm1.2Yy mutation (0 available); any Vangl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryonic cilium location or orientation ( J:162640 )
• positioning of the posterior notochord (node) cilia is randomized unlike in wild-type mice
• in the posterior notochord (node), cell density is slightly reduced and cilia localization is altered compared to in wild-type mice
abnormal motile primary cilium physiology ( J:162640 )
• nodal flow produces swirling vortices and time to cross the posterior notochord (node) is lengthened compared to in wild-type mice
• unilateral nodal flow in the posterior notochord (node) is compromised compared to in wild-type mice
• however, cilia in the posterior notochord beat at the same speed and direction as in wild-type mice
abnormal embryo turning ( J:162640 )
• embryos fail to turn unlike wild-type mice
abnormal notochord morphology ( J:162640 )
• cell density and the number of posteriorly localized basal bodies in the posterior notochord (node) are decreased compared to in wild-type mice

growth/size/body
abnormal prenatal body size ( J:162640 )
• embryos exhibit a reduction in length to width ratio compared with wild-type mice
heterotaxia ( J:162640 )
• mice exhibit left-right asymmetry defects compared with wild-type mice
• however, nodal cilia appear normal
left pulmonary isomerism ( J:162640 )
• mild

nervous system
abnormal cochlear inner hair cell morphology ( J:162640 )
• inner hair cells are misoriented compared to in wild-type mice
abnormal cochlear outer hair cell morphology ( J:162640 )
• outer hair cells are misoriented compared to in wild-type mice

cardiovascular system

respiratory system

hearing/vestibular/ear
abnormal cochlear inner hair cell morphology ( J:162640 )
• inner hair cells are misoriented compared to in wild-type mice
abnormal cochlear outer hair cell morphology ( J:162640 )
• outer hair cells are misoriented compared to in wild-type mice

cellular
abnormal embryonic cilium location or orientation ( J:162640 )
• positioning of the posterior notochord (node) cilia is randomized unlike in wild-type mice
• in the posterior notochord (node), cell density is slightly reduced and cilia localization is altered compared to in wild-type mice
abnormal motile primary cilium physiology ( J:162640 )
• nodal flow produces swirling vortices and time to cross the posterior notochord (node) is lengthened compared to in wild-type mice
• unilateral nodal flow in the posterior notochord (node) is compromised compared to in wild-type mice
• however, cilia in the posterior notochord beat at the same speed and direction as in wild-type mice




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory