Phenotypes associated with this allele

• Allele Symbol: Ncoa3^tm1.1Bwo
• Allele Name: targeted mutation 1.1, Bert W O'Malley
• Allele ID: MGI:4818421
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ncoa3^tm1.1Bwo/Ncoa3^tm1.1Bwo	involves: 129S/SvEv * C57BL/6J	MGI:4818427

Genotype
MGI:4818427

hm1

• Allelic Composition: Ncoa3^tm1.1Bwo/Ncoa3^tm1.1Bwo
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:161276 )

N • mice exhibit normal energy expenditure (oxygen consumption, carbon dioxide generation, and respiratory quotient)

impaired adaptive thermogenesis ( J:161276 )

• mice exhibit a slight protection from decreased body temperature in response to fasting compared with wild-type mice

• however, mice are able to maintain body temperature in response to cold

decreased body temperature ( J:161276 )

• when resting

decreased carbon dioxide production ( J:161276 )

• during exercise-induced stress, mice exhibit decreased carbon dioxide production compared with wild-type mice

• however, carbon dioxide production is normal under normal conditions

decreased oxygen consumption ( J:161276 )

• during exercise-induced stress, mice exhibit decreased oxygen consumption compared with wild-type mice

• however, oxygen consumption is normal under normal conditions

abnormal glucose homeostasis ( J:161276 )

hyperglycemia ( J:161276 )

• whether fasting or fed

impaired glucose tolerance ( J:161276 )

increased liver glycogen level ( J:161276 )

insulin resistance ( J:161276 )

abnormal hormone level ( J:161276 )

decreased circulating glucagon level ( J:161276 )

• in fasting mice

increased circulating insulin-like growth factor I level ( J:161276 )

• in fasting mice

increased circulating leptin level ( J:161276 )

decreased adiponectin level ( J:161276 )

increased liver triglyceride level ( J:161276 )

abnormal exercise endurance ( J:161276 )

• upon exercise-induced stress, mice exhibit a minimal reduction in energy expenditure compared with wild-type mice

increased incidence of tumors by chemical induction ( J:161276 )

• mice exhibit increased diethylnitrosamine (DEN)-induced tumorigenesis (increased number and size) compared with similarly treated wild-type mice

adipose tissue

increased total body fat amount ( J:161276 )

increased fat cell size ( J:161276 )

behavior/neurological

abnormal eating behavior ( J:161276 )

• minor

decreased locomotor activity ( J:161276 )

liver/biliary system

increased liver glycogen level ( J:161276 )

increased liver triglyceride level ( J:161276 )

neoplasm

increased incidence of tumors by chemical induction ( J:161276 )

• mice exhibit increased diethylnitrosamine (DEN)-induced tumorigenesis (increased number and size) compared with similarly treated wild-type mice

digestive/alimentary system

abnormal defecation ( J:161276 )

• mice produce less waste than wild-type mice

cellular

abnormal cell differentiation ( J:161276 )

• mouse embryonic fibroblast cells exhibit reduced adipocyte differentiation potential compared with wild-type cells

renal/urinary system

oliguria ( J:161276 )

growth/size/body

increased body weight ( J:161276 )

• just before weaning and continuing throughout life