Ncoa3^tm1.1Bwo
Targeted Allele Detail

Summary

• Symbol: Ncoa3^tm1.1Bwo
• Name: nuclear receptor coactivator 3; targeted mutation 1.1, Bert W O'Malley
• MGI ID: MGI:4818421
• Synonyms: SRC-3^delta
• Gene: Ncoa3 Location: Chr2:165834557-165915162 bp, + strand Genetic Position: Chr2, 86.22 cM, cytoband H2-H4
• Alliance: Ncoa3^tm1.1Bwo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161276
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitution results in the amino acid substitution of alanine in four conserved phosphorylation sites (S498A and S536A in exon 10, S847A and S850A in exon 12). An frt flanked neo cassette was inserted downstream of exon 10. Flp mediated recombination removed the neo cassette. (J:161276)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncoa3 Mutation: 231 strains or lines available

References

• Original: J:161276 York B, et al., Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11122-7
• All: 1 reference(s)