Analysis Tools
immune system
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• in the thymus
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hematopoietic system
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• in the thymus
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Allele Symbol Allele Name Allele ID |
Tg(Cd8a*-cre)B8Asin transgene insertion B8, Alfred Singer MGI:4462361 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the thymus
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• in the thymus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the thymus
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• in the thymus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the thymus
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• in the thymus but not the periphery due to lymphopenia-induced homeostatic expansion
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• of invariant NK T cells in the thymus, spleen and liver
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• of CD4 single-positive thymocytes expressing Foxp3
• however, these cells are restored by a cross with Tg(LCKprBCL2)36Sjk mice
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• in the thymus
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• in the thymus but not the periphery due to lymphopenia-induced homeostatic expansion
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• of invariant NK T cells in the thymus, spleen and liver
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• of CD4 single-positive thymocytes expressing Foxp3
• however, these cells are restored by a cross with Tg(LCKprBCL2)36Sjk mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• of invariant NK T cells as in Il2rgtm1.1Asin/Il2rgtm1Wjl Tg(Cd8a*-cre)#Asin mice
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• of invariant NK T cells as in Il2rgtm1.1Asin/Il2rgtm1Wjl Tg(Cd8a*-cre)#Asin mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the thymus, as in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice
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• in the thymus, as in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the thymus and periphery, worse than in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice
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• in the thymus and periphery, worse than in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the thymus and periphery
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• in the thymus and periphery
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2
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• modest effect on T cell development
• however, mice exhibit normal differentiation from double positive to single positive thymocyte and differentiation of single positive thymocytes
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• in the lymph nodes
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• at the double positive stage
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• in the lymph nodes
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• in the lymph nodes
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• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2
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• modest effect on T cell development
• however, mice exhibit normal differentiation from double positive to single positive thymocyte and differentiation of single positive thymocytes
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• in the lymph nodes
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• at the double positive stage
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• in the lymph nodes
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• in the lymph nodes
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• at the double positive stage
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• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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