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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Adipoq-cre)#Pesch
transgene insertion, Philipp E Scherer
MGI:4462047
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Grb10tm1.1Fliu/Grb10tm1.1Fliu
Tg(Adipoq-cre)#Pesch/0
involves: 129S/SvEv * FVB MGI:6107175
cn2
Ap2a2tm1.1Momk/Ap2a2tm1.1Momk
Tg(Adipoq-cre)#Pesch/0
involves: C57BL/6J * C57BL/6N * FVB MGI:8234785


Genotype
MGI:6107175
cn1
Allelic
Composition
Grb10tm1.1Fliu/Grb10tm1.1Fliu
Tg(Adipoq-cre)#Pesch/0
Genetic
Background
involves: 129S/SvEv * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb10tm1.1Fliu mutation (0 available); any Grb10 mutation (56 available)
Tg(Adipoq-cre)#Pesch mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• at 6 months when fed standard chow despite normal food intake, fasting glucose, bone mineral density and lean mass
• when fed a high-fat diet despite no increase in food intake
• however, rapamycin treatment reduced fat mass
• when fed standard chow or a high-fat diet
• however, cell number is normal and rapamycin treatment reduced cell size
• brown adipose tissue exhibit larger multilocular lipid droplets compared to in control mice
• however, rapamycin treatment reduced lipid accumulation in brown adipose tissue
• in epididymal and inguinal white adipose tissue when fed standard chow or a high-fat diet
• however, cell number is normal and rapamycin treatment reduced cell size
• increased lipid accumulation
• reduced beta-adrenoceptor agonist-stimulated glycerol and fatty acid release from brown, inguinal and epididymal fat of fasted mice
• decreased fatty acid oxidation in brown adipocytes

homeostasis/metabolism
• in brown adipocytes
• when fed a high-fat diet despite no increase in food intake
• cold-exposed mice exhibit reduced body temperatures compared with control mice
• when fed a high-fat diet
• in cold-exposed mice
• in cold-exposed mice despite normal activity levels and respiratory quotient
• when fed a high-fat diet
• when fed a high-fat diet

growth/size/body
• at 6 months when fed standard chow despite normal food intake, fasting glucose, bone mineral density and lean mass
• when fed a high-fat diet despite no increase in food intake
• however, rapamycin treatment reduced fat mass
• at 6 months despite normal food intake, fasting glucose, bone mineral density and lean mass
• however, rapamycin treatment reduced body weight gain
• at 6 months
• however, rapamycin treatment reduced body weight gain
• when fed a high-fat diet despite no increase in food intake

liver/biliary system
• when fed a high-fat diet

cellular
• in brown adipocytes




Genotype
MGI:8234785
cn2
Allelic
Composition
Ap2a2tm1.1Momk/Ap2a2tm1.1Momk
Tg(Adipoq-cre)#Pesch/0
Genetic
Background
involves: C57BL/6J * C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap2a2tm1.1Momk mutation (0 available); any Ap2a2 mutation (75 available)
Tg(Adipoq-cre)#Pesch mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• gain less weight on a high fat diet for 8 weeks (26% increase vs 50% increase for diet matched controls)
• remain lean after 12 weeks on a high fat diet

adipose tissue
• brown adipose tissue is denser with fewer lipid droplets especially under high fat diet conditions
• significant brown adipose tissue atrophy on either a normal chow or high fat diet
• a 30% increase in mtDNA content normalized to nuclear DNA content in inguinal white adipose tissue from mice on a high fat diet compared to diet matched controls
• decrease in adipocyte diameters but no change in numbers in epididymal white adipose tissue
• in mice on a high fat diet compared to diet matched controls
• in mice on a high fat diet compared to diet matched controls
• superoxide generation is enhanced in adipocytes isolated from inguinal white adipose tissue on a normal chow diet
• superoxide generation in adipocytes from mice on a high fat diet is similar to wild-type cells from diet matched mice

homeostasis/metabolism
• decrease palmitate oxidation in epididymal what adipose tissue explants from mice on a normal chow diet compared to diet matched controls
• increased in palmitate oxidation in inguinal white adipose tissue and brown adipose tissue explants from mice on a high fat diet compared to diet matched controls
• however, palmitate oxidation in explants from muscle or epididymal what adipose tissue is similar to wild-type controls
• cold intolerant independent of diet
• in high fat diet fed mice compared to diet matched controls
• decreased by 40% in mice on a high fat diet
• when on a high fat diet remain reliant on fatty acid (FA) utilization in a thermoneutral environment
• in mice on a high fat diet compared to diet matched controls
• gain less weight on a high fat diet for 8 weeks (26% increase vs 50% increase for diet matched controls)
• remain lean after 12 weeks on a high fat diet
• increased VCO2 at night and during the day in mice on a high fat diet compared to diet matched controls
• increased VO2 at night and during the day when on a high fat diet compared to diet matched controls
• in inguinal white adipose tissue explants from mice on a high fat diet oxygen consumption normalized to nuclear DNA content is increased 2-fold
• in epididymal white adipose tissue explants from mice on a high fat diet in the presence of pyruvate or FCCP oxygen consumption rate is increased
• on a high fat diet
• after 12 or 21 weeks on a high fat diet

cellular
• a 30% increase in mtDNA content normalized to nuclear DNA content in inguinal white adipose tissue from mice on a high fat diet compared to diet matched controls
• increased mitochondrial volume density is elevated more than 2 fold in inguinal white adipose tissue from high fat diet fed mice compared to diet matched controls
• however, there is no sign of damaged or swollen mitochondria
• enhanced mitochondrial uncoupled respiration in cultured adipocytes from mice on a normal chow or high fat diet
• increased induction of mitochondrial biogenesis in inguinal white adipose tissue explants from mice on a high fat diet compared to diet matched controls
• decrease palmitate oxidation in epididymal what adipose tissue explants from mice on a normal chow diet compared to diet matched controls
• increased in palmitate oxidation in inguinal white adipose tissue and brown adipose tissue explants from mice on a high fat diet compared to diet matched controls
• however, palmitate oxidation in explants from muscle or epididymal what adipose tissue is similar to wild-type controls

immune system
• on a high fat diet display reduced diet-induced adipose tissue inflammation

liver/biliary system





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/29/2025
MGI 6.24
The Jackson Laboratory