Phenotypes associated with this allele

• Allele Symbol: Igh-7^tm1Lcwu
• Allele Name: targeted mutation 1, Lawren C Wu
• Allele ID: MGI:4461407
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh-7^tm1Lcwu/Igh-7^tm1Lcwu	involves: C57BL/6	MGI:4461423

Genotype
MGI:4461423

hm1

• Allelic Composition: Igh-7^tm1Lcwu/Igh-7^tm1Lcwu
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased mature B cell number ( J:161452 )

• B cells with surface IgE molecules are induced to apoptosis by treatment with antibody specific for human M1'

• untreated mice have a normal phenotype

• overall numbers of mature B cells are unaffected by antibody treatment

decreased IgE level ( J:161452 )

• mice treated with antibody specific to human M1' display drastically reduced levels of specific IgE

• levels of specific Ig belonging to other classes are normal

hematopoietic system

decreased mature B cell number ( J:161452 )

• B cells with surface IgE molecules are induced to apoptosis by treatment with antibody specific for human M1'

• untreated mice have a normal phenotype

• overall numbers of mature B cells are unaffected by antibody treatment

decreased IgE level ( J:161452 )

• mice treated with antibody specific to human M1' display drastically reduced levels of specific IgE

• levels of specific Ig belonging to other classes are normal