About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxa3tm3.1Nrm
targeted mutation 3.1, Nancy R Manley
MGI:4461308
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hoxa3tm1Mrc/Hoxa3tm3.1Nrm
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S7/SvEvBrd * C57BL/6J * CBA/J MGI:4461312
cn2
 		Hoxa3tm2Nrm/Hoxa3tm3.1Nrm
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: C3H * C57BL/6 * CBA/J MGI:4461313


Genotype
MGI:4461312
cn1
Allelic
Composition		 Hoxa3tm1Mrc/Hoxa3tm3.1Nrm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Hoxa3tm1Mrc mutation (0 available); any Hoxa3 mutation (24 available)
Hoxa3tm3.1Nrm mutation (0 available); any Hoxa3 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
ectopic parathyroid gland ( J:161296 )
• at E15.5, parathyroids are ectopically attached to the thymus unlike in wild-type mice
• however, parathyroid morphology is normal
ectopic thymus ( J:161296 )
• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice
• however, thymic lobe morphology is normal

hematopoietic system
ectopic thymus ( J:161296 )
• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice
• however, thymic lobe morphology is normal

immune system
ectopic thymus ( J:161296 )
• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice
• however, thymic lobe morphology is normal




Genotype
MGI:4461313
cn2
Allelic
Composition		 Hoxa3tm2Nrm/Hoxa3tm3.1Nrm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: C3H * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Hoxa3tm2Nrm mutation (0 available); any Hoxa3 mutation (24 available)
Hoxa3tm3.1Nrm mutation (0 available); any Hoxa3 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
ectopic parathyroid gland ( J:161296 )
• at E15.5, parathyroids are ectopically attached to the thymus unlike in wild-type mice
• however, parathyroid morphology is normal
ectopic thymus ( J:161296 )
• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice
• however, thymic lobe morphology is normal

immune system
ectopic thymus ( J:161296 )
• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice
• however, thymic lobe morphology is normal

hematopoietic system
ectopic thymus ( J:161296 )
• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice
• however, thymic lobe morphology is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory