Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm3Itan mutation
(0 available);
any
Runx1 mutation
(35 available)
|
|
|
immune system
|
• early hematopoietic lymphoid tissue inducer (LTi) lineage specification is impaired compared to in wild-type mice
|
|
• mice exhibit impaired Peyer's patches compared with wild-type mice
|
hematopoietic system
endocrine/exocrine glands
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm3Itan mutation
(0 available);
any
Runx1 mutation
(35 available)
|
|
|
mortality/aging
hematopoietic system
|
• the number of colony forming units in culture (CFU-Cs) from E8.5 embryo and yolk sac is decreased 4-fold compared to CFU-Cs produced from wild-type tissues
• at E8.5, CFU-C tend to be smaller than wild-type colonies
• the number of CFU-Cs generated from E11.5 yolk sac is decreased 3.4-fold compared to CFU-Cs produced from wild-type tissues
• the number of CFU-Cs generated from E11.5 vitelline and umbilical arteries is decreased 7.2-fold compared to CFU-Cs produced from wild-type tissues
• however, colony size is normal at E11.5
|
|
• in the bone marrow and peripheral blood
|
|
• in the bone marrow and peripheral blood
|
|
• hematopoietic stem cells and progenitor cells are increased in the bone marrow and peripheral blood compared to in wild-type mice
|
immune system
|
• in the bone marrow and peripheral blood
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm1Spe mutation
(1 available);
any
Runx1 mutation
(35 available)
Runx1tm3Itan mutation
(0 available);
any
Runx1 mutation
(35 available)
|
|
|
mortality/aging
N |
• unlike Runx1tm1Spe homozygotes, mice do not exhibit embryonic lethality
|
hematopoietic system
N |
• unlike Runx1tm1Spe homozygotes, mice do not exhibit fetal liver anemia
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm3Itan mutation
(0 available);
any
Runx1 mutation
(35 available)
Tg(Runx1-GFP)#Itan mutation
(0 available)
|
|
|
cardiovascular system
|
• mice exhibit a severe decrease in GFP+ hematopoietic cells or clusters in the dorsal aorta compared with Tg(Runx1-GFP)#Itan mice
|
hematopoietic system
|
• mice exhibit a severe decrease in GFP+ hematopoietic cells or clusters in the dorsal aorta compared with Tg(Runx1-GFP)#Itan mice
|