All Phenotypes Il6ra<tm1.1Drew> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il6ra^tm1.1Drew
targeted mutation 1.1, Angela Drew
MGI:4456449

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il6ra^tm1.1Drew/Il6ra^tm1.1Drew	involves: C57BL/6 * C57BL/6N * SJL	MGI:4456456
cn2	Il6ra^tm1.1Drew/Il6ra^tm1.1Drew Tg(GFAP-cre)8Gtm/0	involves: C57BL/6 * C57BL/6N * CBA	MGI:5577074
cn3	Il6ra^tm1.1Drew/Il6ra^tm1.1Drew Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: C57BL/6 * C57BL/6N * SJL	MGI:4456458
cn4	Il6ra^tm1.1Drew/Il6ra^tm1.1Drew Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: C57BL/6 * C57BL/6N * SJL	MGI:4456459

Allelic Composition	Il6ra^tm1.1Drew/Il6ra^tm1.1Drew
Genetic Background	involves: C57BL/6 * C57BL/6N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6ra^tm1.1Drew mutation (1 available); any Il6ra mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:160966 )

Allelic Composition	Il6ra^tm1.1Drew/Il6ra^tm1.1Drew Tg(GFAP-cre)8Gtm/0
Genetic Background	involves: C57BL/6 * C57BL/6N * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6ra^tm1.1Drew mutation (1 available); any Il6ra mutation (35 available)
Tg(GFAP-cre)8Gtm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211914 )

• fewer than expected mice are present at weaning with only a few mice dying after birth

behavior/neurological

behavior/neurological phenotype ( J:211914 )

N	• mice exhibit normal vertical exploratory activity (rearings)

abnormal emotion/affect behavior ( J:211914 )

• in the hole-board test, mice exhibit increased number of unexplored squares and a tendency for defecation compared with control mice

• mice exhibit decreased time in the center of a plus maze compared with control mice

abnormal head movements ( J:211914 )

• in the hole-board test, mice exhibit increased number of head dips but not time spent dipping their head compared with control mice

nervous system

nervous system phenotype ( J:211914 )

N	• mice exhibit normal levels of gliosis

Allelic Composition	Il6ra^tm1.1Drew/Il6ra^tm1.1Drew Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: C57BL/6 * C57BL/6N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6ra^tm1.1Drew mutation (1 available); any Il6ra mutation (35 available)
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:160966 )

N	• mice exhibit normal acute-phase response to turpentine challenge

Allelic Composition	Il6ra^tm1.1Drew/Il6ra^tm1.1Drew Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: C57BL/6 * C57BL/6N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6ra^tm1.1Drew mutation (1 available); any Il6ra mutation (35 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased acute inflammation ( J:160966 )

• acute-phase response to turpentine challenge is completely muted compared to in similarly treated wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:160966 )

N	• mice exhibit normal healing of large wounds

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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