Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Jcbr mutation
(0 available);
any
Mapk8 mutation
(71 available)
Tg(Ckmm-cre)5Khn mutation
(4 available)
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growth/size/body
N |
• whether fed standard chow or a high fat diet, mice exhibit normal body composition
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Jcbr mutation
(0 available);
any
Mapk8 mutation
(71 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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homeostasis/metabolism
liver/biliary system
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• in mice fed a high-fat diet
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• in mice fed a high-fat diet
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• mice fed a high-fat diet exhibit reduced hepatic triglyceride levels compared with similarly treated wild-type mice
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growth/size/body
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• beginning at 4 weeks, mice fed a standard or high-fat diet exhibit decreased body weight compared with wild-type mice
• however, reduced body weight in response to leptin treatment is normal
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• following intracerebroventricular insulin treatment whether fed a standard or high-fat diet
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• whether fed a standard or high-fat diet, mice exhibit reduced naso-anal length compared with similarly treated wild-type mice
• mice fed a high-fat diet fail to exhibit as much of an increase in naso-anal length as in wild-type mice
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behavior/neurological
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• following intracerebroventricular insulin treatment whether fed a standard or high-fat diet
• however, decreased food intake induced by leptin treatment is normal
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