Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mapk8tm1Jcbr targeted mutation 1, Jens C Bruning MGI:4441327 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• whether fed standard chow or a high fat diet, mice exhibit normal body composition
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| N |
• whether fed standard chow or a high fat diet, mice exhibit normal energy homeostasis, insulin sensitivity and glucose homeostasis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in mice fed a standard diet
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• in fed or fasted mice on a standard diet
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• in mice fed a standard diet
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• in mice fed a high-fat diet
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• in fasted and fed mice on a high-fat diet
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• in mice fed a standard or high-fat diet
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• in mice fed a high-fat diet
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• whether fed a standard or high-fat diet, intracerebroventricular insulin treatment reduces food intake, triggers weight loss, and improves hypothalamic insulin action unlike in similarly treated wild-type mice
• mice fed a high fat diet exhibit improved performance in an insulin tolerance test compared with wild-type mice
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• in mice fed a high-fat diet
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• in mice fed a high-fat diet
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• in mice fed a high-fat diet
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• in mice fed a high-fat diet
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• mice fed a high-fat diet exhibit reduced hepatic triglyceride levels compared with similarly treated wild-type mice
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• beginning at 4 weeks, mice fed a standard or high-fat diet exhibit decreased body weight compared with wild-type mice
• however, reduced body weight in response to leptin treatment is normal
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• following intracerebroventricular insulin treatment whether fed a standard or high-fat diet
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• whether fed a standard or high-fat diet, mice exhibit reduced naso-anal length compared with similarly treated wild-type mice
• mice fed a high-fat diet fail to exhibit as much of an increase in naso-anal length as in wild-type mice
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• following intracerebroventricular insulin treatment whether fed a standard or high-fat diet
• however, decreased food intake induced by leptin treatment is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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