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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bhlhe22tm3.1(cre)Meg
targeted mutation 3.1, Michael E Greenberg
MGI:4440745
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bhlhe22tm3.1(cre)Meg/Bhlhe22+
Gata3tm1Jfz/Gata3tm2Gsv
Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:5581690
cn2
 		Bhlhe22tm3.1(cre)Meg/Bhlhe22+
Gata3tm1Jfz/Gata3tm1Jfz 		involves: 129S1/Sv * 129X1/SvJ MGI:5581689
cn3
 		Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg
Tg(CAG-Bgeo/GFP)21Lbe/0 		involves: 129S1/Sv * 129X1/SvJ MGI:4440936
cn4
 		Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ 		involves: 129/Sv * 129S4/SvJaeSor MGI:4440937
cn5
 		Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+ 		involves: 129/Sv * 129X1/SvJ MGI:4440935


Genotype
MGI:5581690
cn1
Allelic
Composition		 Bhlhe22tm3.1(cre)Meg/Bhlhe22+
Gata3tm1Jfz/Gata3tm2Gsv
Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm3.1(cre)Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Gata3tm1Jfz mutation (0 available); any Gata3 mutation (31 available)
Gata3tm2Gsv mutation (0 available); any Gata3 mutation (31 available)
Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal inner hair cell synaptic ribbon morphology ( J:207904 )
• partial rescue of ribbon loss observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice
abnormal cochlear ganglion morphology ( J:207904 )
• partial rescue of synaptic defects observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice

hearing/vestibular/ear
abnormal inner hair cell synaptic ribbon morphology ( J:207904 )
• partial rescue of ribbon loss observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice




Genotype
MGI:5581689
cn2
Allelic
Composition		 Bhlhe22tm3.1(cre)Meg/Bhlhe22+
Gata3tm1Jfz/Gata3tm1Jfz
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm3.1(cre)Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Gata3tm1Jfz mutation (0 available); any Gata3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cochlear ganglion morphology ( J:207904 )
• cochlear synaptic loss is more severe than in Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice




Genotype
MGI:4440936
cn3
Allelic
Composition		 Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg
Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm1Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Bhlhe22tm3.1(cre)Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal spinal cord dorsal horn morphology ( J:158273 )
• in the superficial laminae of spinal cord, there are significantly fewer lacZ-marked neurons compared to controls; significant loss of cell bodies and neuropil is observed




Genotype
MGI:4440937
cn4
Allelic
Composition		 Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129/Sv * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm1Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Bhlhe22tm3.1(cre)Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal spinal cord dorsal horn morphology ( J:158273 )
• in the superficial dorsal horn, there are significantly fewer ( about 50%) lacZ-marked neurons compared to controls




Genotype
MGI:4440935
cn5
Allelic
Composition		 Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm1Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Bhlhe22tm3.1(cre)Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Gt(ROSA)26Sortm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal spinal cord dorsal horn morphology ( J:158273 )
• quantification of neurons at P0 shows a 50% decrease in number of marked neurons in superficial dorsal horn compared to controls with no difference in numbers in any other spinal cord region
• significant increase in number of apoptotic cells (marked neurons) in superficial dorsal horn is observed at E18.5, but no difference is observed at E17.5 or 19.5
• partial loss of glutamatergic and GABAergic neurons is observed in dorsal horn
• number of marked neurons in dorsal horn are not different from controls when BrdU labeling is done at E12.5 or E13.5 and analysis is done at E17.5, indicating that neuronal mitosis is not affected




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory