Phenotypes associated with this allele

• Allele Symbol: Slc26a1^tm1Mark
• Allele Name: targeted mutation 1, Daniel Markovich
• Allele ID: MGI:4440647
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc26a1^tm1Mark/Slc26a1^tm1Mark	involves: 129X1/SvJ * CD-1	MGI:4440648

Genotype
MGI:4440648

hm1

• Allelic Composition: Slc26a1^tm1Mark/Slc26a1^tm1Mark
• Genetic Background: involves: 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Urolithiasis in Slc26a1^tm1Mark/Slc26a1^tm1Mark mice

cellular

hepatic necrosis ( J:158567 )

• 12-hour administration of 250 mg/kg acetaminophen leads to liver necrosis which is not seen in similarly treated wild-type controls

abnormal vesicle-mediated transport ( J:158567 )

• oxalate and SO4^2- transport are strongly reduced in basolateral membrane vesicles isolated from kidney, liver, distal ileum, cecum and proximal colon

immune system

kidney inflammation ( J:158567 )

• infiltration of leukocytes around renal cortical vessels

renal/urinary system

increased urine calcium level ( J:158567 )

• urine oxalate/creatinine ratio is significantly increased

increased urine sulfate level ( J:158567 )

• SO4^2-creatinine ratios and the fractional excretion index (FEI) for SO4 are significantly increased

kidney inflammation ( J:158567 )

• infiltration of leukocytes around renal cortical vessels

nephrolithiasis ( J:158567 )

• calcium oxalate crystals are observed in the lumen of kidney cortical tubules and the bladder

homeostasis/metabolism

increased circulating alanine transaminase level ( J:158567 )

• 12-hour administration of 250 mg/kg acetaminophen leads to a 4-fold increase in serum alanine aminotransferase compared to similarly treated wild-type controls

abnormal mineral level ( J:158567 )

• a decrease in oxalate and an increase in cecal sulfate content

increased circulating calcium level ( J:158567 )

• plasma oxalate levels are increased

hyposulfatemia ( J:158567 )

increased urine calcium level ( J:158567 )

• urine oxalate/creatinine ratio is significantly increased

increased urine sulfate level ( J:158567 )

• SO4^2-creatinine ratios and the fractional excretion index (FEI) for SO4 are significantly increased

increased physiological sensitivity to xenobiotic ( J:158567 )

• exposure to acetaminophen results in enhanced liver toxicity compared to wild-type controls

liver/biliary system

hepatic necrosis ( J:158567 )

• 12-hour administration of 250 mg/kg acetaminophen leads to liver necrosis which is not seen in similarly treated wild-type controls

abnormal liver physiology ( J:158567 )

• a single 250-mg/kg dose of acetaminophen leads to a significantly greater reduction in glutathione after 2 hours

digestive/alimentary system

abnormal digestive system physiology ( J:158567 )

• a decrease in cecal oxalate and an increase in cecal sulfate content