Phenotypes associated with this allele
reproductive system
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N |
• despite the decrease in primordial germ cell numbers, germ cell numbers at E18.5 and fertility of adult mice are similar to wild-type controls
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• at E12.5 in the genital ridge
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• increase in the ratio of apoptotic to viable PGCs at E11.5
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cellular
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• at E12.5 in the genital ridge
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• increase in the ratio of apoptotic to viable PGCs at E11.5
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embryo
|
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• at E14.5, the number of LacZ+ neural crest cell-derived cells in the skin is lower in both the head and belly regions than that in NCC-specific heterozygous knockout littermates carrying only one Resttm1.1Yasu allele
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nervous system
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• at E14.5, the number of LacZ+ neural crest cell-derived cells in the skin is lower in both the head and belly regions than that in NCC-specific heterozygous knockout littermates carrying only one Resttm1.1Yasu allele
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mortality/aging
|
|
• mice die within 48 hrs of birth
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nervous system
|
N |
• at E16.5, E18.5 and P0, no significant differences are observed in the number or distribution pattern of melanoblasts in the epidermis of vibrissae, back or abdominal skin relative to control mice
|
mortality/aging
|
N |
• mice are viable and survive to adulthood
|
pigmentation
|
|
• ~60% of mice exhibit a white belly spot of variable size ranging from a few white hairs to a white spot that is ~1 cm in diameter; in contrast, only ~15% of control mice carrying the transgene alone form an extremely small, striated white-haired area on the belly
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integument
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• ~60% of mice exhibit a white belly spot of variable size ranging from a few white hairs to a white spot that is ~1 cm in diameter; in contrast, only ~15% of control mice carrying the transgene alone form an extremely small, striated white-haired area on the belly
|
nervous system
|
N |
• at E16.5, E18.5 and P0, no significant differences are observed in the number or distribution pattern of melanoblasts in the epidermis of vibrissae, back or abdominal skin relative to control mice
|
embryo
|
|
• at E12.5 and E14.5, the number of Dct-LacZ+ cells in the belly region is significantly lower than that in control mice
• at E17.5, the distribution pattern of LacZ+ cells is altered in skin from the abdomen, but not from the back or head
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nervous system
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• at E12.5 and E14.5, the number of Dct-LacZ+ cells in the belly region is significantly lower than that in control mice
• at E17.5, the distribution pattern of LacZ+ cells is altered in skin from the abdomen, but not from the back or head
|
embryo
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• adult mice show a marked reduction in the number of Dct-LacZ+ melanoblasts and/or melanocytes in the white spot of abdominal skin
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nervous system
|
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• adult mice show a marked reduction in the number of Dct-LacZ+ melanoblasts and/or melanocytes in the white spot of abdominal skin
|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation
(1 available);
any
Rest mutation
(95 available)
Tg(Tyr-cre)1Lru mutation
(1 available)
|
|
|
pigmentation
 N |
• mice never form white spots including on the belly region
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation
(1 available);
any
Rest mutation
(95 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
|
pigmentation
|
N |
• mice never form white spots
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation
(1 available);
any
Rest mutation
(95 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
|
pigmentation
|
N |
• mice never form white spots
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation
(1 available);
any
Rest mutation
(95 available)
Tg(Tyr-cre)1Lru mutation
(1 available)
|
|
|
pigmentation
|
N |
• mice never form white spots including on the belly region
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation
(1 available);
any
Rest mutation
(95 available)
Tg(Mpz-cre)26Mes mutation
(2 available)
|
|
|
pigmentation
|
N |
• mice never form white spots including on the belly region
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation
(1 available);
any
Rest mutation
(95 available)
Tg(Mpz-cre)26Mes mutation
(2 available)
|
|
|
pigmentation
|
N |
• mice never form white spots including on the belly region
|
pigmentation
|
N |
• mice never form white spots including on the belly region
|
pigmentation
|
|
• in rare cases (2 of 40), mice develop a small white spot on their forehead
|
integument
|
|
• in rare cases (2 of 40), mice develop a small white spot on their forehead
|
Analysis Tools