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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm6Xu
targeted mutation 6, Yang Xu
MGI:4430743
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Trp53tm6Xu/Trp53tm6Xu
Tg(Lck-cre)1Cwi/0 		involves: 129S4/SvJae MGI:4430744


Genotype
MGI:4430744
cn1
Allelic
Composition		 Trp53tm6Xu/Trp53tm6Xu
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)1Cwi mutation (3 available)
Trp53tm6Xu mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:157041 )
• all die of tumors by 50 weeks of age

neoplasm
increased metastatic potential ( J:157041 )
• unlike in thymocyte conditional null mice (carrying Trp53tm1Brd and Tg(Lck-cre)1Cwi ), about 40% of tumors are metastatic
increased lymphoma incidence ( J:157041 )
• predominantly peripheral and thymic lymphomas by 50 weeks of age

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory