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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sav1tm1.1Rjo
targeted mutation 1.1, Randy L Johnson
MGI:4430538
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sav1tm1.1Rjo/Sav1tm1.1Rjo
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA * CD-1 * SJL MGI:4430543
cn2
 		Sav1tm1.1Rjo/Sav1tm1.1Rjo
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL MGI:4430548
cn3
 		Sav1tm1.1Rjo/Sav1tm1.1Rjo
Tg(MMTV-cre)4Mam/0 		involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL MGI:4430545


Genotype
MGI:4430543
cn1
Allelic
Composition		 Sav1tm1.1Rjo/Sav1tm1.1Rjo
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sav1tm1.1Rjo mutation (0 available); any Sav1 mutation (18 available)
Tg(CAG-cre/Esr1*)5Amc mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased liver tumor incidence ( J:156531 )
• by 14 months of age

liver/biliary system
increased liver tumor incidence ( J:156531 )
• by 14 months of age




Genotype
MGI:4430548
cn2
Allelic
Composition		 Sav1tm1.1Rjo/Sav1tm1.1Rjo
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sav1tm1.1Rjo mutation (0 available); any Sav1 mutation (18 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte proliferation ( J:156531 )
• increased BrdU incorporation
increased liver weight ( J:156531 )
• 10% increase in liver size by 4months of age
increased hepatocellular carcinoma incidence ( J:156531 )
• mice at 13-14 months of age develop large liver tumors that are hepatocellular carcinoma and cholangiocarcinoma like

neoplasm
increased carcinoma incidence ( J:156531 )
• mice at 13-14 months of age develop large liver tumors that are hepatocellular carcinoma and cholangiocarcinoma like
increased hepatocellular carcinoma incidence ( J:156531 )
• mice at 13-14 months of age develop large liver tumors that are hepatocellular carcinoma and cholangiocarcinoma like

cellular
increased hepatocyte proliferation ( J:156531 )
• increased BrdU incorporation

growth/size/body
increased liver weight ( J:156531 )
• 10% increase in liver size by 4months of age




Genotype
MGI:4430545
cn3
Allelic
Composition		 Sav1tm1.1Rjo/Sav1tm1.1Rjo
Tg(MMTV-cre)4Mam/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CD-1 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sav1tm1.1Rjo mutation (0 available); any Sav1 mutation (18 available)
Tg(MMTV-cre)4Mam mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased liver tumor incidence ( J:156531 )
• by 14 months of age

liver/biliary system
increased liver tumor incidence ( J:156531 )
• by 14 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory