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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CAG-cre/Esr1*)1Egwa
transgene insertion 1, Gyohei Egawa
MGI:4430073
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Plxnd1tm1Ddg/Plxnd1tm1.1Tmj
Tg(CAG-cre/Esr1*)1Egwa/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:5052373
cn2
 		Kdrtm1Jrt/Kdrtm1.1Jamb
Tg(CAG-cre/Esr1*)1Egwa/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:5052372
cn3
 		Efnb2tm2And/Efnb2tm2And
Tg(CAG-cre/Esr1*)1Egwa/0 		involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 MGI:4430085
cn4
 		Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem
Tg(CAG-cre/Esr1*)1Egwa/0 		involves: C57BL/6 * CBA * DBA/2 MGI:5052370


Genotype
MGI:5052373
cn1
Allelic
Composition		 Plxnd1tm1Ddg/Plxnd1tm1.1Tmj
Tg(CAG-cre/Esr1*)1Egwa/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnd1tm1.1Tmj mutation (1 available); any Plxnd1 mutation (88 available)
Plxnd1tm1Ddg mutation (0 available); any Plxnd1 mutation (88 available)
Tg(CAG-cre/Esr1*)1Egwa mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increase in extraretinal vascular outgrowth in ischemic Plxnd1tm1.1Tmj/Plxnd1tm1Ddg Tg(CAG-cre/Esr1*)1Egwa/0 retinas

vision/eye
abnormal induced retina neovascularization ( J:173943 )
• tamoxifen-treated mice exhibit increased extraretinal vascular outgrowth in ischemic retinas compared with control mice

cardiovascular system
abnormal induced retina neovascularization ( J:173943 )
• tamoxifen-treated mice exhibit increased extraretinal vascular outgrowth in ischemic retinas compared with control mice




Genotype
MGI:5052372
cn2
Allelic
Composition		 Kdrtm1Jrt/Kdrtm1.1Jamb
Tg(CAG-cre/Esr1*)1Egwa/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1.1Jamb mutation (0 available); any Kdr mutation (67 available)
Kdrtm1Jrt mutation (1 available); any Kdr mutation (67 available)
Tg(CAG-cre/Esr1*)1Egwa mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Suppression of of extraretinal vascular outgrowth in ischemic Kdrtm1.1Jamb/Kdrtm1Jrt Tg(CAG-cre/Esr1*)1Egwa/0 retinas

cardiovascular system
abnormal induced retina neovascularization ( J:173943 )
• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice

vision/eye
abnormal induced retina neovascularization ( J:173943 )
• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice




Genotype
MGI:4430085
cn3
Allelic
Composition		 Efnb2tm2And/Efnb2tm2And
Tg(CAG-cre/Esr1*)1Egwa/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb2tm2And mutation (2 available); any Efnb2 mutation (27 available)
Tg(CAG-cre/Esr1*)1Egwa mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:157054 )
• some pups become frail and subsequently die with tamoxifen treatment on first two days postnatal

growth/size/body
postnatal growth retardation ( J:157054 )
• seen with tamoxifen treatment on first two days postnatal

cardiovascular system
abnormal angiogenesis ( J:157054 )
• with tamoxifen treatment, vascular morphology in the dermis is severely affected, with dilatation of the vascular lumen

integument
integument phenotype ( J:157054 )
N
• with tamoxifen treatment, infiltration of leukocytes is comparable to untreated controls and is not cause of hypercornification
retarded hair growth ( J:157054 )
• seen at P9 with tamoxifen treatment on first two days postnatal
thin hypodermis ( J:157054 )
• seen at P9 seen with tamoxifen treatment on first two days postnatal
small hair follicles ( J:157054 )
• seen with tamoxifen treatment on first two days postnatal, pups have shorter hair follicles
hyperkeratosis ( J:157054 )
• hypercornification of skin is observed seen at P9 with tamoxifen treatment on first two days postnatal
• with tamoxifen treatment, no difference is detected at P4
thick epidermis ( J:157054 )
• seen at P9 with tamoxifen treatment on first two days postnatal
flaky skin ( J:157054 )
• observed initially by P5 and peaking between 1 and 2 weeks of age with tamoxifen treatment on first two days postnatal
abnormal skin physiology ( J:157054 )
• enhanced proliferation of epidermal progenitor cells is detected with tamoxifen treatment at P1-2




Genotype
MGI:5052370
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem
Tg(CAG-cre/Esr1*)1Egwa/0
Genetic
Background		 involves: C57BL/6 * CBA * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(CAG-cre/Esr1*)1Egwa mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Decreased extraretinal vascular outgrowth in ischemic Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem Tg(CAG-cre/Esr1*)1Egwa/0 retinas

cardiovascular system
abnormal induced retina neovascularization ( J:173943 )
• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice

vision/eye
abnormal induced retina neovascularization ( J:173943 )
• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory