Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Akiyoshi Uemura
• MGI ID: MGI:5052360
• Synonyms: R26-Rhoj
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem} page

Decreased extraretinal vascular outgrowth in ischemic Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem}/Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem} Tg(CAG-cre/Esr1*)1Egwa/0 retinas

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173943
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rhoj (MGI:1931551)

• Mutation details: A vector, which contained a floxed neo/stop cassette, the murine cDNA, an FRT-flanked IRES-EGFP cassette, and polyadenylation sequence, was inserted into the locus. (J:173943)

Schematic representation of the targeting strategy for the Gt(ROSA)26Sor^{tm1(CAG-Rhoj,-EGFP)Auem} allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:173943 Fukushima Y, et al., Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice. J Clin Invest. 2011 May 2;121(5):1974-85
• All: 2 reference(s)