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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem
targeted mutation 1, Akiyoshi Uemura
MGI:5052360
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem
Tg(Tek-cre)#Rwng/0 		involves: C57BL/6 * CBA MGI:5052369
cn2
 		Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem
Tg(CAG-cre/Esr1*)1Egwa/0 		involves: C57BL/6 * CBA * DBA/2 MGI:5052370
cn3
 		Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sor+
Tg(Tek-cre)2352Rwng/0 		involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N MGI:5464992


Genotype
MGI:5052369
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem
Tg(Tek-cre)#Rwng/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Tek-cre)#Rwng mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Growth retardation and defective vascular development in Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem Tg(Tek-cre)#Rwng/0 mice

mortality/aging
prenatal lethality, complete penetrance ( J:173943 )
• no neonates are obtained

cardiovascular system

embryo

growth/size/body
embryonic growth retardation ( J:173943 )
• at E10.5




Genotype
MGI:5052370
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem
Tg(CAG-cre/Esr1*)1Egwa/0
Genetic
Background		 involves: C57BL/6 * CBA * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(CAG-cre/Esr1*)1Egwa mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Decreased extraretinal vascular outgrowth in ischemic Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem Tg(CAG-cre/Esr1*)1Egwa/0 retinas

cardiovascular system
abnormal induced retina neovascularization ( J:173943 )
• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice

vision/eye
abnormal induced retina neovascularization ( J:173943 )
• tamoxifen-treated mice exhibit decreased extraretinal vascular outgrowth in ischemic retinas compared with control mice




Genotype
MGI:5464992
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sor+
Tg(Tek-cre)2352Rwng/0
Genetic
Background		 involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Tek-cre)2352Rwng mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Retardation of retinal vascular growth in Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sor+ Tg(Tek-cre)2352Rwng/0 mice

cardiovascular system
abnormal retina vasculature morphology ( J:191977 )
• retinal vascular growth retardation (reduced radial extension) at P4

vision/eye
abnormal retina vasculature morphology ( J:191977 )
• retinal vascular growth retardation (reduced radial extension) at P4




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory