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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mcph1tm1.2Kali
targeted mutation 1.2, Kaiyi Li
MGI:4429492
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mcph1tm1.2Kali/Mcph1tm1.2Kali involves: 129S7/SvEvBrd * C57BL/6J MGI:4429495


Genotype
MGI:4429495
hm1
Allelic
Composition		 Mcph1tm1.2Kali/Mcph1tm1.2Kali
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcph1tm1.2Kali mutation (0 available); any Mcph1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Mcph1tm1.2Kali/Mcph1tm1.2Kali males are infertile and exhibit meiotic defects

mortality/aging
increased mortality induced by gamma-irradiation ( J:156371 )
• when exposed to 7 Gy ionizing radiation, all mice die within 9 days, where 80% of wild-type mice survive
perinatal lethality, incomplete penetrance ( J:156371 )
• birth rate is lower than expected, no time of lethality provided

reproductive system
abnormal spermatid morphology ( J:156371 )
• at P56, absence of spermatids in seminiferous tubules
decreased male germ cell number ( J:156371 )
• fewer spermatocytes are produced in seminiferous tubules
abnormal male meiosis ( J:156371 )
• interstitial initiation of synapsis with asynapsis on either side of the contact
• incomplete, dashed-line shape bivalents in many homologs during zygotene or zygotene/pachytene
• double-strand breaks cannot be appropriately repaired
arrest of male meiosis ( J:156371 )
• meiotic dysregulation at P14, P21, and P56, spermatocytes arrest prior to the pachytene stage
• increase in zygotene spermatocytes and a complete absence of postmeitotic cells
increased male germ cell apoptosis ( J:156371 )
• increase in TUNEL+ cells in tubules
abnormal seminiferous tubule morphology ( J:156371 )
• significantly smaller and thinner than those of wild-type at P28
small testis ( J:156371 )
• testes are consistently smaller especially after 3-weeks of age

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:156371 )
• significantly smaller and thinner than those of wild-type at P28
small testis ( J:156371 )
• testes are consistently smaller especially after 3-weeks of age

cellular
abnormal spermatid morphology ( J:156371 )
• at P56, absence of spermatids in seminiferous tubules
decreased male germ cell number ( J:156371 )
• fewer spermatocytes are produced in seminiferous tubules
abnormal male meiosis ( J:156371 )
• interstitial initiation of synapsis with asynapsis on either side of the contact
• incomplete, dashed-line shape bivalents in many homologs during zygotene or zygotene/pachytene
• double-strand breaks cannot be appropriately repaired
arrest of male meiosis ( J:156371 )
• meiotic dysregulation at P14, P21, and P56, spermatocytes arrest prior to the pachytene stage
• increase in zygotene spermatocytes and a complete absence of postmeitotic cells
increased cellular sensitivity to gamma-irradiation ( J:156371 )
• MEFs are more sensitive to ionizing radiation, as measure by number of cells surviving after 6 days
increased male germ cell apoptosis ( J:156371 )
• increase in TUNEL+ cells in tubules
induced chromosome breakage ( J:156371 )
• increased chromosomal breakage in MEFs 3 and 20 hrs after ionizing radiation treatment

growth/size/body
decreased body weight ( J:156371 )
• at P56 weight is only 80% of wild-type

immune system
abnormal T cell physiology ( J:156371 )
• increase in number of chromosomal aberrations in T cells

hematopoietic system
abnormal T cell physiology ( J:156371 )
• increase in number of chromosomal aberrations in T cells

homeostasis/metabolism
increased mortality induced by gamma-irradiation ( J:156371 )
• when exposed to 7 Gy ionizing radiation, all mice die within 9 days, where 80% of wild-type mice survive




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory