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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ehmt2tm1.1Tara
targeted mutation 1.1, Alexander Tarakhovsky
MGI:4418499
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		\Ehmt2tm1.1Tara/\Ehmt2tm1.1Tara
\Tg(Camk2a-cre)2Gsc/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4418567
cn2
 		\Ehmt2tm1.1Tara/\Ehmt2tm1.1Tara
\Tg(Drd1-cre)EY262Gsat/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4418568
cn3
 		\Ehmt2tm1.1Tara/\Ehmt2tm1.1Tara
\Tg(Drd2-cre)ER44Gsat/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4418569
cn4
 		\Ehmt1tm1.1Tara/\Ehmt1tm1.1Tara
\Ehmt2tm1.1Tara/\Ehmt2tm1.1Tara
\Tg(Camk2a-cre)2Gsc/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4418570


Genotype
MGI:4418567
cn1
Allelic
Composition		 \Ehmt2tm1.1Tara/\Ehmt2tm1.1Tara
\Tg(Camk2a-cre)2Gsc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt2tm1.1Tara mutation (0 available); any Ehmt2 mutation (57 available)
Tg(Camk2a-cre)2Gsc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:155739 )
N
• the specific neuronal cell architecture in the striatum and the hippocampus was not altered

behavior/neurological
impaired behavioral response to xenobiotic ( J:155739 )
• almost completely lack a preference for sucrose
decreased exploration in new environment ( J:155739 )
• starting around 6-8 weeks of age, in an open field make fewer total arm entries in an elevated plus maze
abnormal liquid preference ( J:155739 )
• almost completely lack a preference for sucrose
decreased anxiety-related response ( J:155739 )
• make more entries into and spend more time in open arms in an elevated plus maze
decreased vertical activity ( J:155739 )
• in a new environment
decreased locomotor activity ( J:155739 )
• in a new environment

growth/size/body
obese ( J:155739 )
• almost doubled their body weight as compared to controls by 5-6 months of age




Genotype
MGI:4418568
cn2
Allelic
Composition		 \Ehmt2tm1.1Tara/\Ehmt2tm1.1Tara
\Tg(Drd1-cre)EY262Gsat/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt2tm1.1Tara mutation (0 available); any Ehmt2 mutation (57 available)
Tg(Drd1-cre)EY262Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired behavioral response to xenobiotic ( J:155739 )
• decrease in Drd-1 agonist SKE 81291 induced locomotor and exploratory responses
decreased locomotor activity ( J:155739 )
• decrease in Drd-1 agonist SKE 81291 induced locomotor and exploratory responses

nervous system
nervous system phenotype ( J:155739 )
N
• no major impact on regulation of neuronal morphology and basal electrophysiological features of Drd2-expressing MSNs in the striatum




Genotype
MGI:4418569
cn3
Allelic
Composition		 \Ehmt2tm1.1Tara/\Ehmt2tm1.1Tara
\Tg(Drd2-cre)ER44Gsat/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt2tm1.1Tara mutation (0 available); any Ehmt2 mutation (57 available)
Tg(Drd2-cre)ER44Gsat mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron physiology ( J:155739 )
• small significant negative gain in excitability of medium spiny neurons

behavior/neurological
enhanced behavioral response to xenobiotic ( J:155739 )
• greater increase in locomotor and exploratory behaviors in response to caffeine, a repressor of Drd2.
induced hyperactivity ( J:155739 )
• greater increase in locomotor and exploratory behaviors in response by to caffeine, a repressor of Drd2




Genotype
MGI:4418570
cn4
Allelic
Composition		 \Ehmt1tm1.1Tara/\Ehmt1tm1.1Tara
\Ehmt2tm1.1Tara/\Ehmt2tm1.1Tara
\Tg(Camk2a-cre)2Gsc/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt1tm1.1Tara mutation (0 available); any Ehmt1 mutation (90 available)
Ehmt2tm1.1Tara mutation (0 available); any Ehmt2 mutation (57 available)
Tg(Camk2a-cre)2Gsc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased exploration in new environment ( J:155739 )
• travel significantly less than control mice in a new environment
decreased vertical activity ( J:155739 )
• reduction in vertical episodes in a new environment
decreased locomotor activity ( J:155739 )
• travel significantly less than control mice in a new environment




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory