Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt2tm1.1Tara mutation
(0 available);
any
Ehmt2 mutation
(55 available)
Tg(Drd2-cre)ER44Gsat mutation
(2 available)
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nervous system
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• small significant negative gain in excitability of medium spiny neurons
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behavior/neurological
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• greater increase in locomotor and exploratory behaviors in response to caffeine, a repressor of Drd2.
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• greater increase in locomotor and exploratory behaviors in response by to caffeine, a repressor of Drd2
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt1tm1.1Tara mutation
(0 available);
any
Ehmt1 mutation
(90 available)
Ehmt2tm1.1Tara mutation
(0 available);
any
Ehmt2 mutation
(55 available)
Tg(Camk2a-cre)2Gsc mutation
(2 available)
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behavior/neurological
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• travel significantly less than control mice in a new environment
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• reduction in vertical episodes in a new environment
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• travel significantly less than control mice in a new environment
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt2tm1.1Tara mutation
(0 available);
any
Ehmt2 mutation
(55 available)
Tg(Camk2a-cre)2Gsc mutation
(2 available)
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nervous system
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N |
• the specific neuronal cell architecture in the striatum and the hippocampus was not altered
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behavior/neurological
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• almost completely lack a preference for sucrose
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• starting around 6-8 weeks of age, in an open field make fewer total arm entries in an elevated plus maze
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• almost completely lack a preference for sucrose
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• make more entries into and spend more time in open arms in an elevated plus maze
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growth/size/body
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• almost doubled their body weight as compared to controls by 5-6 months of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt2tm1.1Tara mutation
(0 available);
any
Ehmt2 mutation
(55 available)
Tg(Drd1-cre)EY262Gsat mutation
(2 available)
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behavior/neurological
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• decrease in Drd-1 agonist SKE 81291 induced locomotor and exploratory responses
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• decrease in Drd-1 agonist SKE 81291 induced locomotor and exploratory responses
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nervous system
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N |
• no major impact on regulation of neuronal morphology and basal electrophysiological features of Drd2-expressing MSNs in the striatum
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Analysis Tools